Increased levels of Muellerian-inhibiting substance could mean greater breast cancer risk

Oct 09, 2009

Women with increased levels of Müllerian inhibiting substance (MIS), best known for regulating in utero sexual differentiation in boys, may be at a greater risk for breast cancer, according to a new study published online October 9 in the .

To determine whether MIS levels were associated with breast cancer risk, Joanne F. Dorgan, Ph.D., MPH, of the Fox Chase Cancer Center in Philadelphia, and colleagues conducted a prospective case-control study of 309 participants who were registered in the Columbia, Missouri Bank. Blood samples were donated by women with in situ or who, at the time of donation, were free of cancer. Each of 105 breast cancer patients was matched to two control subjects. MIS was measured in serum using an enzyme-linked immunosorbent assay.

Researchers found that increasing MIS serum concentrations were associated with increased breast cancer risk in this population.

"Additional research is needed, including confirmatory epidemiological studies on the association of serum MIS with and studies aimed at identifying the biological mechanism underlying the association," the authors write.

Source: (news : web)

Explore further: New cancer drug target involving lipid chemical messengers

add to favorites email to friend print save as pdf

Related Stories

Estrogen therapy increases benign breast disease risk

Apr 08, 2008

Women who took conjugated equine estrogen, a commonly prescribed form of estrogen, had more than twice the risk of developing specific types of benign breast disease as women who took a placebo, according to a randomized ...

Risk of breast cancer and a single-nucleotide polymorphism

Jul 02, 2009

The single-nucleotide polymorphism (SNP) known as 2q35-rs13387042 is associated with increased risk of estrogen receptor (ER) -positive and -negative breast cancer, according to a study published online July 1 in the Journal of ...

No need for gene screens in breast cancer families

Jul 23, 2008

Research reported today should provide relief to women who are worried after a relative's breast cancer diagnosis. The study in the open access journal BMC Cancer shows that a family history of breast cancer does not give a ...

Recommended for you

User comments : 0