ATP is a key to feel warm temperature

Oct 08, 2009

A Japanese research group led by Prof. Makoto Tominaga and Dr. Sravan Mandadi (National Institute for Physiological Sciences: NIPS) found that ATP plays a key role in transmitting temperature information from skin keratinocytes to afferent sensory neurons. Their findings were presented in the Pflugers Archiv European Journal of Physiology published on October 1, 2009.

Hazardous temperatures (extreme hot or cold) are known to be detected by the temperature-activated (thermoTRPs) expressed in free sensory nerve endings. On the other hand, ambient innocuous warm temperatures are sensed by different thermoTRPs, TRPV3 and TRPV4 expressed in skin keratinocytes. Interesting question is, therefore, how our nervous system recognizes the warmth information sensed by the non-excitable epithelial cells.

In a co-culture system, heat-evoked response in DRG neurons was secondary to that in skin keratinocytes, and the DRG responses were diminished by the receptor antagonists. ATP release from keratinocytes was confirmed by 'a bio-sensor system' in which a cell expressing ATP receptors was placed in close proximity to keratinocytes. Warmth-activated TRPV3, rather than TRPV4, was found to be predominantly involved in the ATP release upon heating.

Dr. Tominaga said, "Our findings for the first time explains how ambient temperature information can be sent from skin to . Our results also support the emerging concept of ATP-mediated information transmission in the non-synaptic connections."

Source: National Institute for Physiological Sciences

Explore further: At least four months to contain Ebola: Red Cross chief

add to favorites email to friend print save as pdf

Related Stories

Bladder cells feel stretch

Aug 07, 2009

Japanese research group led by Prof. Makoto Tominaga and Dr. Takaaki Sokabe (National Institute for Physiological Sciences: NIPS), and Prof. Masayuki Takeda, Dr. Isao Araki and Dr. Tsutomu Mochizuki (Yamanashi Univ.), found ...

Painful heat sensed by 'painless' in flies

Sep 30, 2008

Japanese research group led by Prof Makoto Tominaga and Dr Takaaki Sokabe, National Institute for Physiological Sciences (NIPS), Japan, found that a small fly, drosophila, has a receptor for noxious heat. The research group ...

Heat halts pain inside the body

Jul 05, 2006

The old wives' tale that heat relieves abdominal pain, such as colic or menstrual pain, has been scientifically proven by a UCL (University College London) scientist, who will present the findings today at the Physiological ...

Hot peppers really do bring the heat

Aug 06, 2008

Chili peppers can do more than just make you feel hot, reports a study in the August 1 Journal of Biological Chemistry; the active chemical in peppers can directly induce thermogenesis, the process by which cells convert energy ...

Recommended for you

In US, Ebola fears rise but most confident in response

2 hours ago

After two health care workers in Texas were infected with Ebola while caring for a Liberian patient, a poll Tuesday showed a rattled US public that nevertheless stayed confident in the government's response.

'Humbled' NBC cameraman recovers from Ebola

2 hours ago

A US photojournalist said Tuesday he was grateful to be alive after the hospital treating him declared him now free of Ebola, in a minor victory over the virus that has killed more than 4,500 people.

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

Rick69
not rated yet Oct 08, 2009
It would have been nice if this article would at least have some speculation on how this research could have some practicle applications. An example would be that often times elderly people feel the need to turn the heat up excessively in the winter, resulting in wasted energy, high heating bills, etc. How could this research address this problem?