Research points to potential chink in cancer's armor

Oct 06, 2009

Scientists at the University of York have identified and successfully silenced a gene that appears essential to cancer cell survival.

Professor Jo Milner and Dr Shafiq Ahmed, from the YCR Research Unit in the Department of Biology, used a process called to target the JNK2 gene in both cancer and healthy cells. The cancer cells died but the healthy cells were unaffected.

This discovery suggests that the survival of depends upon certain genes which healthy cells can survive without, an important step towards the development of the next generation of cancer treatments.

Dr Ahmed said: "Our results indicate that one day it may be possible to treat cancer without the harmful side-effects so often associated with today's treatments. Our study has identified a cancer-specific target which could be selectively inhibited using small-molecules, or other means, without the use of and chemotherapy."

This laboratory-based work is still at a very early stage and the next step is to test a larger range of different cancer cell types and also to test normal healthy cells from different tissues.

The research, which examined colorectal cancer and breast cancer cell lines among others, was funded by Yorkshire Cancer Research and is published in the journal .

A major aim of Professor Milner's research team is to identify cancer-specific survival genes and to ask if such genes offer a new route for cancer treatment. This field of research has been made possible through the development of RNA interference which allows the silencing of a single gene amongst thousands of genes.

Professor Milner said: "Our approach is now revealing unexpected properties for certain genes including JNK2. We have also studied JNK2's close relative, JNK1, and found that these two genes seem to oppose each other. JNK1 and JNK2 resemble the 'Jekyll and Hyde' for cancer cell survival.

"A further surprise is that the mechanism by which these two function under normal every-day conditions appears distinct from the mechanism which is activated by current anti-cancer therapies."

Dr Kathryn Scott, from Yorkshire Cancer Research, said: "The work of Professor Milner and Dr Ahmed represents another example of the world-class research that Yorkshire Research funds throughout the region."

Source: University of York

Explore further: Common painkillers may help prevent certain skin cancers, study finds

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Mutations need help from aging tissue to cause leukemia

3 hours ago

Why are older people at higher risk for developing cancer? Prevailing opinion holds that, over time, your body's cells accumulate DNA damage and that eventually this damage catches up with the body in a way ...

Specific oxidation regulates cellular functions

8 hours ago

For a long time, hydrogen peroxide has been considered as a dangerous metabolite that can damage cells through oxidation. This, however, is not its only role in the cell. Scientists from the German Cancer Research Center ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.