Antibiotic may be new stroke treatment

Oct 06, 2009

The antibiotic minocycline may revolutionize the treatment of strokes. A new study, published in the open access journal BMC Neuroscience, describes the safety and therapeutic efficacy of the drug in animal models.

Dr. Cesar V. Borlongan from the University of South Florida, USA worked with a team of researchers to test the treatment in laboratory experiments. He said, "To date, the thrombolytic agent tPA is the only effective drug for acute ischemic stroke; however, only about 2% of ischemic stroke patients benefit from this treatment due to its limited therapeutic window. There is a desperate need to develop additional neuroprotective strategies. This research is an important step in rectifying the treatment issues, presenting a new, more effective treatment for stroke patients".

Every 5 minutes someone in the UK has a stroke and stroke currently accounts for almost 10% of deaths worldwide, claiming more lives than HIV/AIDS. During a stroke, a clot prevents blood flow to parts of the brain, which can have wide ranging short-term and long-term implications. This study recorded the effect of intravenous minocycline in both isolated neurons and animal models after a stroke had been experimentally induced. At low doses it was found to have a neuroprotective effect on neurons by reducing apoptosis of and ameliorating behavioral deficits caused by stroke.

According to Dr. Borlongan, "The safety and therapeutic efficacy of low dose minocycline and its robust neuroprotective effects during acute ischemic stroke make it an appealing for stroke therapy. An on-going phase 1 clinical study funded by the National Institutes of Health is exploring the use of intravenous minocycline to treat ".

More information: Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic , Noriyuki Matsukawa, Takao Yasuhara, Koichi Hara, Lin Xu, Mina Maki, Guolong Yu, Yuji Kaneko, Kosei Ojika, David C Hess and Cesar V Borlongan, BMC Neuroscience (in press), http://www.biomedcentral.com/bmcneurosci/

Source: BioMed Central (news : web)

Explore further: Study finds potential genetic link between epilepsy and neurodegenerative disorders

add to favorites email to friend print save as pdf

Related Stories

Not a moment to lose in therapy for acute stroke

Sep 24, 2008

In an editorial response to a report in the September 25 issue of the New England Journal of Medicine on the efficacy of intravenous thrombolysis treatment in the hours after acute ischemic stroke, Patrick Lyden, M.D., profes ...

Old antibiotic may find new life as a stroke treatment

May 19, 2008

An old intravenous antibiotic may have new life as a stroke treatment, researchers say. Minocycline appears to reduce stroke damage in multiple ways – inhibiting white blood cells and enzymes that, at least ...

Study opens way for later treatment of acute stroke

Sep 15, 2008

The time span in which treatment should be given for acute ischaemic stroke – i.e. stroke caused by a clot or other obstruction to the blood supply – can be lengthened. This according to a study from the Swedish medical ...

Recommended for you

Study links enzyme to autistic behaviors

46 minutes ago

Fragile X syndrome (FXS) is a genetic disorder that causes obsessive-compulsive and repetitive behaviors, and other behaviors on the autistic spectrum, as well as cognitive deficits. It is the most common ...

A new cause of mental disease?

6 hours ago

Astrocytes, the cells that make the background of the brain and support neurons, might be behind mental disorders such as depression and schizophrenia, according to new research by a Portuguese team from ...

Molecular basis of age-related memory loss explained

Jul 22, 2014

From telephone numbers to foreign vocabulary, our brains hold a seemingly endless supply of information. However, as we are getting older, our ability to learn and remember new things declines. A team of ...

The neurochemistry of addiction

Jul 22, 2014

We've all heard the term "addictive personality," and many of us know individuals who are consistently more likely to take the extra drink or pill that puts them over the edge. But the specific balance of ...

User comments : 0