Childhood kidney disorder has lasting effects

Sep 24, 2009

A kidney condition that can arise in children and was until recently believed to disappear after puberty may persist into adulthood and cause significant long-term complications, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that better treatment options are needed for children with the disorder, called minimal change nephrotic syndrome.

Many children who develop minimal change nephrotic syndrome—a disorder that largely affects the blood filtering structures of the kidneys—can be successfully treated with prednisone. The cause of the syndrome is unknown but may be related to an autoimmune illness. Unfortunately, 10% to 40% of patients suffer relapses after childhood and must be treated long-term with .

To determine the lasting health effects of minimal change nephrotic syndrome and its treatment in patients who are not cured during childhood, Henriette Kyreileis, MD, PhD (Radboud University Nijmegen Medical Centre, The Netherlands) and Elena Levtchenko, MD, PhD (University Hospitals Leuven, Belgium), and their colleagues studied 15 adult patients with the disease. The investigators ran a number of tests on the patients—including blood and urine analyses; semen analyses in men; x-ray exams; eye exams; and genetic tests.

Hypertension was found in 7 of the 15 patients, and osteoporosis was present in five of the patients. Eye exams revealed nearsightedness in 10 of the patients and cataracts in three of the patients. In the eight male participants in the study, low sperm count was found in one patient, reduced sperm motility was detected in four patients, and defective sperm were present in six patients.

The analysis revealed that while adults being treated for minimal change nephrotic syndrome may maintain normal , they frequently experience other serious health problems. Long-term immunosuppressive treatments may be the cause and/or may contribute to the development of these adverse effects. "Our study underscores a need for more effective and less toxic therapies for relapsing minimal change nephrotic syndrome," the authors wrote.

More information: The article, entitled "Long-Term Outcome of Biopsy-Proven, Frequently Relapsing Minimal-Change Nephrotic Syndrome in Children," will appear online on September 24, 2009, doi 10.2215/CJN.05691108

Source: American Society of Nephrology (news : web)

Explore further: Cholera kills six in northern Nigeria: state official

add to favorites email to friend print save as pdf

Related Stories

Weight loss is good for the kidneys

Sep 17, 2009

Losing weight may preserve kidney function in obese people with kidney disease, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that t ...

Rituximab reduces kidney inflammation in patients with lupus

Mar 04, 2009

Treatment with the targeted drug rituximab can significantly benefit some patients with severe lupus nephritis who do not respond to conventional therapy, according to a study appearing in an upcoming issue of the Clinical Jo ...

Increasing the number of kidney transplants

Aug 20, 2009

In most transplant centers, the kidneys of very young deceased donors are transplanted together into one patient. According to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (C ...

Hello wearable kidney, goodbye dialysis machine

Aug 20, 2009

Researchers are developing a Wearable Artificial Kidney for dialysis patients, reports an upcoming paper in the Clinical Journal of the American Society of Nephrology (CJASN). "Our vision of a technological breakthrough ...

Recommended for you

Asthma drug may help those with chronic hives

9 hours ago

(HealthDay)—A drug already used to treat moderate-to-severe allergic asthma appears to offer relief to people with chronic hives who haven't been helped by standard medications, new research suggests.

Study compares deep vein thrombosis therapies (Update)

12 hours ago

Patients who have a clot in their legs and are considering whether to be treated with traditional blood-thinning medication or undergo a minimally-invasive catheter-based clot removal procedure should feel comfortable that ...

User comments : 0