Novel genetic region identified for childhood asthma in Mexicans

Aug 28, 2009

Genetic variants in a region on chromosome 9q may influence asthma development in Mexican children, according to research published in the August 28 issue of the open-access journal PLoS Genetics.

Researchers from the National Institute of Environmental Health Sciences and the National Institute of Public Health (Mexico) and their collaborators at universities in the US and the UK conducted a genome-wide association (GWA) study, in which they looked at over 500,000 variants across the genome in 492 Mexican children with asthma and their parents to identify novel genes that may influence asthma development. The work points to the chromosome 9q21.31 region as a novel candidate region for .

Asthma is a leading chronic childhood disease that is influenced by both genetic and environmental factors. However, few genes have been consistently associated with the disease. GWA studies have successfully identified novel genes for many common diseases, but to date there have been only a handful of GWA studies focused on asthma and even fewer focused on asthma in Hispanic populations.

The researchers also examined ancestry in this Mexican population and found that the chromosome 9q21.31 region may underlie some of the differences in childhood asthma prevalence that have been observed across ethnic groups. It remains unclear why have lower rates of asthma than some other groups.

The chromosome 9q21.31 variants associated with childhood asthma in this study are located near the TLE4 gene, but the researchers state that "further work is needed to decipher whether TLE4 or a nearby gene explains the signals from the chromosome 9q21.31 region." In addition, it is likely that multiple genetic and environmental risk factors underlie the development of childhood asthma, and the researchers conclude that studies with very large sample sizes will be needed to identify the important interacting risk factors.

More information: Hancock DB, Romieu I, Shi M, Sienra-Monge J-J, Wu H, et al. (2009) Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for in Mexican Children. PLoS Genet 5(8): e1000623. doi:10.1371/journal.pgen.1000623

Source: Public Library of Science (news : web)

Explore further: Could ibuprofen be an anti-aging medicine? Popular over-the counter drug extends lifespan in yeast, worms and flies

add to favorites email to friend print save as pdf

Related Stories

More findings on gene involved in childhood asthma

Sep 15, 2008

Asthma researchers have found that a gene variant known to raise the risk of childhood asthma in European children plays a similar role in white American children, but not in African American children.

Genetic predisposition increases childhood asthma risk

Aug 21, 2007

Children who carry variations in specific genes that metabolize vehicle emissions are more susceptible to developing asthma, particularly if they live near major roadways, a study led by researchers at the University of Southern ...

Aussie study links asthma to smoking

Sep 04, 2006

Australian scientists who spent nearly 40 years on a research program say asthma in adults can be the result of maternal smoking.

Recommended for you

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.