Antimicrobial antibodies in celiac disease: Trick or treat?

Aug 26, 2009

Anti-microbial antibody formation has been reported in celiac disease. Relatively high positivity rates were observed for the conventional antibodies, for example, ASCA, anti-OmpW, and anti-I2, and they were known to decrease after a successful gluten free-diet. The importance of newly discovered inflammatory bowel disease-associated antibodies (including anti-glycan antibodies and anti-OMP) in celiac disease is not sure. The presence of anti-microbial antibodies in relation to clinical presentation of the disease and NOD2/CARD15 mutations was also not investigated.

A research article to be published on August 21, 2009 in the addresses this question. Hungarian researchers from the University of Debrecen in Debrecen and the Semmelweis University in Budapest have shown in a well-characterized CD cohort that the anti-glycan antibody positivity is a common feature of celiac disease at the time of diagnosis and is lost after long-term gluten-free diet. The positivity rate and titers at diagnosis are as high as observed in Crohn's disease. The presence of anti-glycan antibodies is associated with the presenting symptoms, especially with severe malabsorption but not with mutations in NOD2/CARD15. No higher prevalence of anti-microbial antibodies is observed in the unaffected, first-degree relatives of this patient cohort.

Although the new data presented in the article may add new pieces to the puzzle of the anti-microbial antibody formation, the authors believe that it also assist to re-evaluate recently proposed genetically drived mechanism. Serological response to various microbial antigens might be considered a universal marker of the enhanced translocation of the gut microflora through the impaired small bowel mucosa both in celiac and Crohn's disease patients.

More information: Papp M, Foldi I, Altorjay I, Palyu E, Udvardy M, TumpekJ, Sipka S, Korponay-Szabo IR, Nemes E, Veres G, Dinya T, Tordai A, Andrikovics H, Norman GL, Lakatos PL. Antimicrobial antibodies in celiac disease: Trick or treat? World J Gastroenterol 2009; 15(31): 3891-3900 www.wjgnet.com/1007-9327/15/3891.asp

Source: World Journal of Gastroenterology (news : web)

Explore further: Unidentified fever kills 13 in DR Congo in 10 days

add to favorites email to friend print save as pdf

Related Stories

No link found between autism and celiac disease

May 01, 2007

Contrary to previous studies, autistic children are no more likely than other children to have celiac disease, according to new research that will be presented at the American Academy of Neurology’s 59th Annual Meeting ...

Anti-HAV antibodies in beta-thalassemia

Apr 30, 2008

Thalassemic patients were found to present a higher prevalence of anti-HAV IgG antibodies than matched healthy subjects from the same geographic area. This finding is difficult to explain, but it may be attributed to the ...

Predictors of disease behavior change in Crohn’s disease

Aug 10, 2009

A research team from Hungary investigated the probability of disease behavior changes in a well-characterized Crohn's disease cohort with strict clinical follow-up. They found that perianal disease, small bowel disease, smoking, ...

Recommended for you

Ebola death toll rises to 1,427: WHO

10 hours ago

The death toll from the Ebola outbreak sweeping through west African countries has risen to 1,427 out of more than 2,600 cases, the World Health Organization said Friday.

User comments : 0