Gallbladder emptying in primary sclerosing cholangitis patients

Aug 10, 2009

Primary sclerosing cholangitis (PSC) is an idiopathic chronic cholestatic inflammatory liver disease characterized by diffuse fibrosing inflammation of intra- and/or extrahepatic bile ducts, resulting in bile duct obliteration, biliary cirrhosis, and eventually hepatic failure. One of the most common symptoms at the time of presentation of PSC is mild to severe abdominal pain localized in the right upper quadrant. However, the mechanisms responsible for the abdominal pain in PSC are not fully understood.

A research team led by Karouk Said from Karolinska University Hospital addressed this question. Their study will be published on July 28, 2009 in the World Journal of Gastroenterology.

In this study, 20 patients with PSC and 10 healthy subjects were investigated. Gallbladder fasting volume, ejection fraction and residual volume after ingestion of a test meal were compared in patients with PSC and healthy controls using . Symptoms, thickness and contrast enhancement of the gallbladder wall and the presence of cystic duct strictures were also assessed.

Median fasting gallbladder volume in patients with PSC [67 (19-348) mL] was twice that in healthy controls [32 (16-55) mL] (P < 0.05). the median postprandial gallbladder volume in patients with psc was significantly larger than that in healthy controls (p < 0.05). there was no difference in ejection fraction, gallbladder emptying volume or mean thickness of the gallbladder wall between psc patients and controls. contrast enhancement of the gallbladder wall in psc patients was higher than that in controls; (69% ± 32%) and (42% ± 21%) (p < 0.05). no significant association was found between the gallbladder volumes and occurrence of abdominal pain in patients and controls.

This concluded that PSC patients have increased fasting gallbladder volume. Gallbladder mucosal dysfunction secondary to chronic cholecystitis, may be a possible mechanism for increased gallbladder volume. Gallbladder size or emptying does not seem to be involved in the development of in patients with PSC.

More information: Said K, Edsborg N, Albiin N, Bergquist A. emptying in patients with primary sclerosing cholangitis. World J Gastroenterol 2009; 15(28): 3498-3503 http://www.wjgnet.com/1007-9327/15/3498.asp

Source: (news : web)

Explore further: Liberia's Sirleaf sees signs of Ebola 'stabilisation'

add to favorites email to friend print save as pdf

Related Stories

Researchers find a new role for a 'Foxy Old Gene'

Aug 01, 2008

Researchers at the University of Pennsylvania School of Medicine have discovered that a protein called FOXA2 controls genes that maintain the proper level of bile in the liver. FOXA2 may become the focus for ...

Gallbladder removed without external incisions

Jul 28, 2008

In April of last year, surgeons at NewYork-Presbyterian Hospital/Columbia University Medical Center made headlines by removing a women's gallbladder through her uterus using a flexible endoscope, aided by several external ...

Recommended for you

Ebola death toll passes 3,300: WHO

49 minutes ago

The death toll in the world's worst-ever Ebola epidemic has now soared past 3,300, with the virus killing almost half of the more than 7,000 people it has infected, according to World Health Organization figures released ...

Dallas ER sent Ebola-infected patient home

1 hour ago

A Dallas emergency room sent a man with Ebola home last week, even though he told a nurse that he had been in disease-ravaged West Africa, and officials at the hospital are considering if they would have ...

US hunts contacts of seriously ill Ebola patient

2 hours ago

US health officials scoured the Dallas area Wednesday for people—including schoolchildren—who came in contact with a Liberian man who was diagnosed with Ebola, as it emerged a hospital mix-up saw him initially turned ...

Australia lifts Ebola donation to $16 million

2 hours ago

Australia more than doubled its donation to the fight against Ebola in West Africa to 18 million Australian dollars ($16 million) on Thursday, but resisted demands to send personnel.

User comments : 0