Transplanted neurons develop disease-like pathology in Huntington's patients

Jul 20, 2009

The results of a recent study published in PNAS question the long-term effects of transplanted cells in the brains of patients suffering from Huntington's disease. This study, conducted jointly by Dr. Francesca Cicchetti of Université Laval in Quebec, Canada, Dr. Thomas B. Freeman of the University of South Florida, USA, and colleagues provides the first demonstration that transplanted cells fail to offer a long-term replacement for degenerating neurons in patients with Huntington's disease.

Huntington's disease is a neurodegenerative disease of genetic origin that targets a particular type of neuron. The loss of these neurons is responsible for the appearance of involuntary movements as well as cognitive and psychiatric impairments. Over a decade ago, Dr. Thomas Freeman of the University of South Florida initiated a clinical trial of neural cell transplantation in Huntington's diseased patients in an attempt to alleviate the dreadful symptoms that characterize this disease.

Some patients demonstrated some mild, transient clinical benefits that lasted for about 2 years. However, the loss of functional recovery after this indicated that graft survival and functionality may be jeopardized long- term.

This post-mortem study of 3 cases is the first demonstration that 1) graft survival is indeed attenuated long-term, 2) grafts undergo degeneration that resembles the pathology observed in , and 3) the brain's inflammatory response could contribute to the compromised survival of grafted cells. The authors also demonstrated that cortical that develop Huntington's disease synapse on the grafts and may cause neurotoxicity to healthy cells, inducing grafted neuronal cell death.

Despite the excitement regarding cell transplantation therapy utilizing embryonic or stem , these results raise concerns for the therapeutic potential of transplantation as a treatment option for Huntington's disease. However, these observations suggest new potential mechanisms involved in the development of the disease. A more in-depth investigation could lead to the development of novel therapeutic strategies. The control of patient immune and inflammatory responses holds therapeutic potential, and Cicchetti et al. are continuing their research in that direction.

Source: Université Laval

Explore further: Missing protein restored in patients with muscular dystrophy

add to favorites email to friend print save as pdf

Related Stories

New hope for Huntington's sufferers

Aug 22, 2007

A major breakthrough in the understanding and potential treatment of Huntington's disease has been made by scientists at the University of Leeds.

Recommended for you

Student seeks to improve pneumonia vaccines

14 hours ago

Almost a million Americans fall ill with pneumonia each year. Nearly half of these cases require hospitalization, and 5-7 percent are fatal. Current vaccines provide protection against some strains of the ...

Seabed solution for cold sores

16 hours ago

The blue blood of abalone, a seabed delicacy could be used to combat common cold sores and related herpes virus following breakthrough research at the University of Sydney.

Better living through mitochondrial derived vesicles

Aug 19, 2014

(Medical Xpress)—As principal transformers of bacteria, organelles, synapses, and cells, vesicles might be said to be the stuff of life. One need look no further than the rapid rise to prominence of The ...

Zebrafish help to unravel Alzheimer's disease

Aug 19, 2014

New fundamental knowledge about the regulation of stem cells in the nerve tissue of zebrafish embryos results in surprising insights into neurodegenerative disease processes in the human brain. A new study by scientists at ...

User comments : 0