Researchers investigate high-risk populations for bladder-cancer screenings

Jul 16, 2009

A new study by UT Southwestern Medical Center researchers sheds light on the challenges involved in identifying which high-risk population would benefit most from bladder-cancer screening.

Large-scale screening of people at high risk for developing invasive could result in earlier diagnosis and improved . Bladder cancer is the fourth most common cancer in men and the fifth most common cancer overall. In the early stages of the disease, it's common to have no signs or symptoms. Smoking has been proven to increase the risk of the disease.

"At this time bladder cancer screening is not the standard of care," said Dr. Yair Lotan, associate professor of urology and senior author of the study appearing online and in a future edition of The . "Although progress has been made in diagnosis, those efforts have translated into minimal survival benefit. In order to get the most benefit from the added cost of screening, we need to identify the appropriate population to screen."

In the study researchers used a point-of-care urine-based test called NMP22 BladderChek to screen 1,502 subjects without symptoms who are at high risk for bladder cancer based on age, smoking history and occupational exposure.

Patients for the study were recruited from well-patient clinics at UT Southwestern and the Dallas Veterans Affairs from March 2006 to November 2007. Those selected were over 50 years old, had smoked for 10 years or more, or had worked for 15 years or more in a high-risk occupation, such as in the dye, petroleum or chemical industries. Participants with other conditions that might lead to false-positive tests were excluded from the study.

Of the 1,502 participants, 85 tested positive for proteins that indicate the possible presence of a bladder tumor; 69 of those agreed to undergo cystoscopy. Only two, however, were found to have noninvasive bladder cancer. The majority of these participants had undergone urinalysis within three years of screening. At the one-year follow-up, two more were found to have cancer, and these patients were over 60 and had more than 42 pack-years of smoking.

"We did expect to find more cases," Dr. Lotan said. "The significance is that even with high-risk patients, only a few had cancer. What that means is we need to find a higher-risk group either by increasing screening to over the age of 60 instead of 50 or looking at individuals with a longer smoking history."

Dr. Lotan said that abstaining from or quitting smoking is the most effective way to prevent and that people should see a urologist immediately if they see blood in their urine or are found to have microscopic blood in their urine.

Source: UT Southwestern Medical Center (news : web)

Explore further: Discovery could lead to new cancer treatment

add to favorites email to friend print save as pdf

Related Stories

Patients unaware of link between smoking and bladder cancer

Jul 08, 2008

Even though cigarette smoking accounts for up to half of all bladder cancer cases, few people are aware of the connection – including more than three-quarters of patients who have bladder cancer, according to a new study ...

Selenium may prevent high risk-bladder cancer

Dec 08, 2008

A study published in the December issue of Cancer Prevention Research, a journal of the American Association for Cancer Research, suggests that selenium, a trace mineral found in grains, nuts and meats, may aid in the pr ...

UF scientists work to develop simple bladder cancer test

Jul 05, 2007

University of Florida researchers have identified a set of proteins that appear to signal the presence of bladder cancer, a discovery they hope will lead to a simple, fast and noninvasive test that can detect the disease ...

Recommended for you

Discovery could lead to new cancer treatment

Aug 29, 2014

A team of scientists from the University of Colorado School of Medicine has reported the breakthrough discovery of a process to expand production of stem cells used to treat cancer patients. These findings could have implications ...

Is the HPV vaccine necessary?

Aug 29, 2014

As the school year starts in full swing many parents wonder if their child should receive the HPV vaccine, which is recommended for girls ages 11-26 and boys 11-21. There are a lot of questions and controversy around this ...

User comments : 0