Study using structural MRI may help accurately diagnose dementia patients

Jul 11, 2009

A new Mayo Clinic study may help physicians differentially diagnose three common neurodegenerative disorders in the future. The study will be presented at the Alzheimer's Association International Conference on Alzheimer's Disease on July 11 in Vienna.

In this study, Mayo Clinic researchers developed a framework for MRI-based differential diagnosis of three common neurodegenerative disorders: Alzheimer's disease, frontotemporal lobar degeneration, and Lewy body disease using Structural MRI. Currently, examination of the brain at is the only way to confirm with certainty that a patient had a specific form of dementia.

The framework, which is called "STructural Abnormality iNDex" or STAND-Map, shows promise in accurately diagnosing dementia patients while they are alive. The rationale is that if each can be associated with a unique pattern of specific on MRI, then it may be possible to differentially diagnose new patients. The study looked at 90 patients from the Mayo Clinic database who were confirmed to have only a single dementia pathology and also underwent an MRI at the time of clinical diagnosis of dementia. Using the STAND-Map framework, researchers predicted an accurate pathological diagnosis 75 to 80 percent of the time.

"The STAND-Map framework might have great potential in early diagnosis of dementia patients," says Prashanthi Vemuri, Ph.D., a senior research fellow at the Mayo Clinic aging and dementia imaging research lab and lead author of the study. "The next step would be to test the framework on a larger population to see if we can replicate these results and improve the accuracy level we achieved in this proof of concept study. In turn, this may lead to better treatment options for ."

Source: Mayo Clinic (news : web)

Explore further: Researcher using next-generation sequencing to rapidly identify pathogens

add to favorites email to friend print save as pdf

Related Stories

Violent sleep disorder linked to a form of dementia

May 17, 2007

Mayo Clinic researchers and a group of international collaborators have discovered a correlation between an extreme form of sleep disorder and eventual onset of parkinsonism or dementia. The findings appear in the current ...

Personality changes may help detect form of dementia

May 28, 2007

ST. PAUL, MN – A simple personality test could help doctors detect dementia with Lewy bodies, a form of dementia often confused with Alzheimer's disease, sooner, according to a study published in the May 29, 2007, issue ...

Computers could be used to diagnose Alzheimer's disease

Feb 22, 2008

Computers are able to diagnose Alzheimer's disease faster and more accurately than experts, according to research published in the journal Brain. The findings may help ensure that patients are diagnosed earlier, increasing treatm ...

Recommended for you

Liberia closes borders and steps up Ebola screening

3 hours ago

Liberian President Ellen Johnson Sirleaf has announced the closure of most of the Ebola-hit country's land borders, with stringent medical checks being stepped up at airports and major trade routes.

User comments : 0