Ageing Brains Show Great Promise for Rejuvenation

Jun 24, 2009

(PhysOrg.com) -- UQ neuroscientists have, for the first time, been able to demonstrate that moderate exercise significantly increases the number of neural stem cells in the ageing brain.

In research published in Stem Cells, Dr Daniel Blackmore and his colleagues at the Queensland Institute (QBI) have shown that moderate exercise directly increases the number of stem cells in the ageing brain.

Despite the conventional wisdom that we only have a set number of neurons or , neuroscientists have known for some time that, in healthy brains, the creation of new neurons is an ongoing and lifelong mechanism.

However, it has also been known for more than a decade that the number of new neurons we produce slowly declines with age.

According to QBI neuroscientist Dr Blackmore, researchers are interested in finding ways to stimulate the production of neurons to negate any decline brought about by age or disease.

"Our findings suggest that moderate exercise, from early to late in life, can have a very positive effect," Dr Blackmore said.

In controlled models of ageing, the number of produced by animals participating in voluntary exercise (running wheel) were significantly higher than in animals of the same age which did not exercise (no running wheel).

"Investigating the mechanism by which neural stem cell numbers are altered will undoubtedly increase our understanding of how the brain responds to its environment," Dr Blackmore said.

"Ultimately, this should allow us to discover how to harness the brain's regenerative capacity, and to bring about new and effective treatments for conditions caused by trauma, disease, or even normal ageing."

"The brain's ability, even at an advanced age, to respond in a positive manner is very exciting as it extends the time-frame in which manipulation is possible."

QBI Director Professor Perry Bartlett FAA said the research represented another significant understanding of the why neural stem cells were so important to brain function.

"It is the first experimental data that shows how we can change the propensity of the brain to make new neurons through increasing the number of stem cells - even in the aged animal," Professor Bartlett said.

"We can now show that exercise directly causes an increase in the number of stem cells in the brain.

"Stem cells develop into neurons and a good supply of is essential for good mental health," he said.

The research paper " increases neural stem cell number in a GH-dependent manner, augmenting the regenerative response in aged mice” by Dr Daniel Blackmore, Dr Mohammad Golmohammadi, Beatrice Large, Dr Michael Waters and Dr Rodney Rietze appeared in the 14 May online edition of .

Provided by University of Queensland (news : web)

Explore further: Know the brain, and its axons, by the clothes they wear

add to favorites email to friend print save as pdf

Related Stories

Stem cells are good for the brain

Jul 15, 2008

For some years, scientists have been speculating over why stem cells exist in the brain, as brain regeneration is limited. A German team of neuroscientists believe these stem cells help keep the brain healthy and active.

Recommended for you

Know the brain, and its axons, by the clothes they wear

Apr 18, 2014

(Medical Xpress)—It is widely know that the grey matter of the brain is grey because it is dense with cell bodies and capillaries. The white matter is almost entirely composed of lipid-based myelin, but ...

Turning off depression in the brain

Apr 17, 2014

Scientists have traced vulnerability to depression-like behaviors in mice to out-of-balance electrical activity inside neurons of the brain's reward circuit and experimentally reversed it – but there's ...

Rapid whole-brain imaging with single cell resolution

Apr 17, 2014

A major challenge of systems biology is understanding how phenomena at the cellular scale correlate with activity at the organism level. A concerted effort has been made especially in the brain, as scientists are aiming to ...

User comments : 4

Adjust slider to filter visible comments by rank

Display comments: newest first

hrfJC
2.6 / 5 (5) Jun 25, 2009
Neuron regeneration is indeed good news for seniors like myself. Exercise increases cardiac output and presumably also increases blood flow needed for cell regeneration in the brain. Improved brain function, manifesting as higher cognition scores, has also been reported from drinking natural non-Dutched cocoa resulting in measurably wider "scrubbed" carotid arteries, hence greater blood flow to the brain.
hrfJC, retired chemist
podizzle
1 / 5 (1) Jun 26, 2009
"Ultimately, this should allow us to discover how to harness the brain's regenerative capacity, and to bring about new and effective treatments for conditions caused by trauma, disease, or even normal ageing." I'm going to take a wild guess and say the answer will be moderate exercise.
thales
3.7 / 5 (3) Jun 26, 2009
Crap, another reason to exercise.
BrianH
1 / 5 (1) Jun 26, 2009
thales;
what you said! I was initially excited by the prospect, but of course there had to be a catch. >:(

More news stories

Atom probe assisted dating of oldest piece of earth

(Phys.org) —It's a scientific axiom: big claims require extra-solid evidence. So there were skeptics in 2001 when University of Wisconsin-Madison geoscience professor John Valley dated an ancient crystal ...

ISEE-3 comes to visit Earth

(Phys.org) —It launched in 1978. It was the first satellite to study the constant flow of solar wind streaming toward Earth from a stable orbit point between our planet and the sun known as the Lagrangian ...