Is 31P MRS a useful tool for evaluating early acute hepatic radiation injury?

Jun 23, 2009

Acute hepatic radiation injury could lead to necrosis of hepatocytes, fatty degeneration and hepatic fibrosis. At the present, the gold standard test is liver biopsy. However, this procedure is invasive, uncomfortable for the patients and sometimes results in serious complications. 31P magnetic resonance spectroscopy (MRS) has been used to study liver metabolism in vivo for several years.

A research team led by Jian-Shan Mao from Zhejiang University investigated whether changes of 31P MRS in the liver with early acute radiation injury were related to the liver damage score (LDS) and pathologic changes. They also determined the value of 31P MRS in detecting early acute hepatic radiation injury, and identified the most valuable phosphorylated metabolite for detecting acute hepatic injury. Their study will be published on June 14, 2009 in the .

In this study, 30 rabbits which received different radiation doses (ranging 5-20 Gy) were used to establish acute hepatic injury models. Blood biochemical tests, 31P MRS and pathological examinations were carried out 24 h after irradiation. The degree of injury was evaluated according to LDS and pathology. Ten healthy rabbits served as controls. The MR examination was performed on a 1.5 T imager using a 1H/31P surface coil by the 2D chemical shift imaging technique. The relative quantities of phosphomonoesters (PME), phosphodiesters (PDE), inorganic phosphate (Pi) and adenosine triphosphate (ATP) were measured.

They found that there were significant differences of ATP relative quantification among control group, mild injured group, moderate injured group, and severe injured group according to both LDS grading and pathological grading, respectively, and it decreased progressively with the increased degree of injury (r = -0.723, P = 0.000).

The relative quantification of PME and Pi decreased significantly in the severe injured group, and the difference between the control group and severe injured group was significant (P < 0.05) according to lds grading and pathological grading, respectively. there were no significant differences among groups according to lds grading, and no significant differences between the control group and experimental groups according to pathological grading. significant differences were only found in pde/atp between the moderate injured group, the severe injured group and the control group, the mild injured group. no significant difference was found in other ratios of relative quantification of phosphorus metabolites.

These results indicate that 31P MRS is a useful method to evaluate early acute hepatic radiation injury. The relative quantification of hepatic ATP levels, which can reflect the pathological severity of acute hepatic radiation injury, is correlated with LDS. This study may be particularly useful for allowing clinical detection of early acute hepatic injury with 31P MRS in the future.

More information: Yu RS, Hao L, Dong F, Mao JS, Sun JZ, Chen Y, Lin M, Wang ZK, Ding WH. Biochemical metabolic changes assessed by 31P after radiationinduced hepatic injury in rabbits. World J Gastroenterol 2009; 15(22): 2723-2730 http://www.wjgnet.com/1007-9327/15/2723.asp

Source: World Journal of Gastroenterology (news : web)

Explore further: Twitter increasingly used to share urological meeting info

add to favorites email to friend print save as pdf

Related Stories

Cathepsin B increases apoptosis in fulminant hepatic failure

Mar 20, 2009

The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic failure, but increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis. It is not known if cathepsin ...

How did glycine significantly decrease liver injury?

Oct 31, 2008

The nonessential amino acid glycine has been shown to be anti-inflammatory in several animal injury models. Recent studies demonstrated that dietary glycine protected both the lung and liver against lethal doses of endotoxin ...

Recommended for you

Exploring 3-D printing to make organs for transplants

Jul 30, 2014

Printing whole new organs for transplants sounds like something out of a sci-fi movie, but the real-life budding technology could one day make actual kidneys, livers, hearts and other organs for patients ...

High frequency of potential entrapment gaps in hospital beds

Jul 30, 2014

A survey of beds within a large teaching hospital in Ireland has shown than many of them did not comply with dimensional standards put in place to minimise the risk of entrapment. The report, published online in the journal ...

Key element of CPR missing from guidelines

Jul 29, 2014

Removing the head tilt/chin lift component of rescue breaths from the latest cardiopulmonary resuscitation (CPR) guidelines could be a mistake, according to Queen's University professor Anthony Ho.

Burnout impacts transplant surgeons (w/ Video)

Jul 28, 2014

Despite saving thousands of lives yearly, nearly half of organ transplant surgeons report a low sense of personal accomplishment and 40% feel emotionally exhausted, according to a new national study on transplant surgeon ...

User comments : 0