Brain irradiation in lung cancer

Jun 03, 2009

A national Radiation Therapy Oncology Group (RTOG) study led by a Medical College of Wisconsin Cancer Center physician at Froedtert Hospital in Milwaukee has found that a course of radiation therapy to the brain after treatment for locally advanced non-small cell lung cancer reduced the risk of metastases to the brain within the first year after treatment. The study was presented at the American Society of Clinical Oncology annual meeting in Orlando, June 1.

"With improved treatments for non-small cell lung , patients are living longer and we are seeing more metastases," says study author Elizabeth Gore, M.D. "This study compared the efficacy of prophylactic (preventive) cranial irradiation (PCI) vs. observation in these patients, and found that those not receiving cranial irradiation were two and one-half times more likely to develop brain metastasis than those who did."

The study analyzed 356 patients. While the results did not show a statistically significant difference in survival between the two groups, it did show that PCI significantly decreased the incidence of brain during the first year post-treatment. Dr. Gore anticipates that additional study of the impact of PCI --on neuro-psychological function and quality of life in these patients-- will help determine if use of PCI should become standard care.

Source: Medical College of Wisconsin (news : web)

Explore further: No increased risk of second cancers with radiotx in pelvic CA

add to favorites email to friend print save as pdf

Related Stories

Drug combination shrinks breast cancer metastases in brain

Dec 16, 2007

A combination of a "targeted" therapy and chemotherapy shrank metastatic brain tumors by at least 50 percent in one-fifth of patients with aggressive HER2-positive breast cancer, according to data presented by Dana-Farber ...

Recommended for you

Scientists zero in on how lung cancer spreads

Dec 24, 2014

Cancer Research UK scientists have taken microscopic images revealing that the protein ties tethering cells together are severed in lung cancer cells - meaning they can break loose and spread, according to ...

Scientists identify rare cancer's genetic pathways

Dec 24, 2014

An international research team, including four Simon Fraser University scientists, has identified the "mutational landscape" of intrahepatic cholangiocarcinoma (ICC), a rare, highly fatal form of liver cancer that disproportionately ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.