Brain irradiation in lung cancer

Jun 03, 2009

A national Radiation Therapy Oncology Group (RTOG) study led by a Medical College of Wisconsin Cancer Center physician at Froedtert Hospital in Milwaukee has found that a course of radiation therapy to the brain after treatment for locally advanced non-small cell lung cancer reduced the risk of metastases to the brain within the first year after treatment. The study was presented at the American Society of Clinical Oncology annual meeting in Orlando, June 1.

"With improved treatments for non-small cell lung , patients are living longer and we are seeing more metastases," says study author Elizabeth Gore, M.D. "This study compared the efficacy of prophylactic (preventive) cranial irradiation (PCI) vs. observation in these patients, and found that those not receiving cranial irradiation were two and one-half times more likely to develop brain metastasis than those who did."

The study analyzed 356 patients. While the results did not show a statistically significant difference in survival between the two groups, it did show that PCI significantly decreased the incidence of brain during the first year post-treatment. Dr. Gore anticipates that additional study of the impact of PCI --on neuro-psychological function and quality of life in these patients-- will help determine if use of PCI should become standard care.

Source: Medical College of Wisconsin (news : web)

Explore further: DNA blood test detects lung cancer mutations

Related Stories

Drug combination shrinks breast cancer metastases in brain

Dec 16, 2007

A combination of a "targeted" therapy and chemotherapy shrank metastatic brain tumors by at least 50 percent in one-fifth of patients with aggressive HER2-positive breast cancer, according to data presented by Dana-Farber ...

Recommended for you

DNA blood test detects lung cancer mutations

Apr 17, 2015

Cancer DNA circulating in the bloodstream of lung cancer patients can provide doctors with vital mutation information that can help optimise treatment when tumour tissue is not available, an international group of researchers ...

Tumors prefer the easy way out

Apr 17, 2015

Tumor cells become lethal when they spread. Blocking this process can be a powerful way to stop cancer. Historically, scientists thought that tumor cells migrated by brute force, actively pushing through whatever ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.