Hyperferritinemia is another surrogate marker of advanced liver disease

May 13, 2009

High serum ferritin, being a hallmark of hereditary hemochromatosis , is frequently found in chronic hepatitis C, alcoholic or non-alcoholic steatohepatitis and non-alcoholic fatty liver disease patients . A study in Italy has investigated the link between ferritin and steatosis in a non-obese cohort of non-alcoholic patients. In southern European populations, high ferritin levels, after exclusion of diagnosis of HH, represent a risk factor for steatosis and clinical relevance, being associated with low platelet count.

Patients with chronic (HCV) infection often have elevated serum iron indices, but these do not accurately reflect hepatic iron content, nor are they able to predict clinically important endpoints, such as progression of fibrosis and responsiveness to interferon-based regimens. Studies that attempt to link iron and the course of chronic hepatitis C have been inconclusive. In C, steatosis is a common histological finding, occurring in 30%-70% of such patients. The biological mechanism underlying steatosis in HCV infection is not definitively understood, and is considered to be multifactorial with metabolic mechanisms, including insulin resistance and overload.

A research article to be published on May 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Licata from Gastroenterology and Hepatology Unit of Palermo University analyzed in a cross-sectional study, a cohort of non-obese, non-alcoholic patients with compensated chronic liver disease characterized by elevated serum ferritin levels, of varying etiology, excluding hemochromatosis, to reassess the link between hyperferritinemia and other markers of the metabolic syndrome, mainly steatosis. All data provide further evidence that hyperferritinemia might be another surrogate marker of advanced liver disease of any etiology.

More information: Licata A, Nebbia ME, Cabibbo G, Lo Iacono G, Barbaria F, Brucato V, Alessi N, Porrovecchio S, Di Marco V, Craxě A, Cammà C. Hyperferritinemia is a risk factor for steatosis in chronic . World J Gastroenterol 2009; 15(17): 2132-2138 http://www.wjgnet.com/1007-9327/15/2132.asp

Source: World Journal of Gastroenterology (news : web)

Explore further: Mali announces new Ebola case

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Mali announces new Ebola case

16 hours ago

Mali announced Saturday a new case of Ebola in a man who is fighting for his life in an intensive care unit in the capital Bamako.

Plague outbreak kills 40 in Madagascar: WHO

17 hours ago

An outbreak of plague has killed 40 people in Madagascar, the World Health Organization said, warning that the disease could spread rapidly in the country's densely populated capital Antananarivo.

UN chief: Ebola cases in Mali a 'deep concern'

Nov 21, 2014

The United Nations chief warned Friday that Ebola may be easing in part of West Africa but is still hitting hard in other areas and outpacing the international response.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.