Heart protein regulates blood vessel maintenance

May 11, 2009

Researchers identify a protein that regulates the physical state of blood vessels. The biochemical processes involved in this regulation are important in the study of cardiovascular health.

In a study led by Akiko Hata, PhD, of Tufts University School of Medicine, researchers have shown that a protein expressed in the heart, FHL2, inhibits the genes necessary for the quiescence of vascular smooth (vSMCs), which line . Vascular smooth muscle cells undergo a process in diseases such as atherosclerosis or normal tissue damage caused by balloon angioplasty where they transition between a resting and proliferative state. The ability to transition between the two states is necessary for the normal development of blood vessels, regulating blood pressure, and repairing vessels that suffer from injury.

"By understanding the pathways that modulate vSMCs, we are closer to being able to develop reagents to ameliorate abnormal function of blood vessels," says Hata, associate professor at Tufts University School of Medicine and a member of the biochemistry program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts.

The researchers have previously shown that BMPs (Bone Morphogenetic Proteins) play a role in the maintenance of smooth muscle cells in the pulmonary artery. In this study, the research demonstrates that FHL2 (Four-and-a-Half LIM Domain Protein 2) inhibits activation of genes that are involved in contraction of smooth muscle cells by at least one of the BMPs.

"We also found that FHL2 is important in the regulation of vasomotor tone, or the contraction and relaxation of muscles in the blood vessel. This is important because dysfunction in vasomotor tone is thought to cause high blood pressure. Our study demonstrates that FHL2 is essential in modulating the physical state of vSMCs, which is essential in regulating vascular motor function," says Hata.

More information: Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna, G, and Hata A. The Journal of Biological Chemistry. 2009. (May 8); 284 (19): 13202-13212. "The Four-and-a-half LIM Domain Protein 2 Regulates Vascular Smooth Muscle Phenotype and Vascular Tone." Published online March 5, 2009, doi: 10.1074/jbc.M900282200

Source: Tufts University

Explore further: Jumping hurdles in the RNA world

add to favorites email to friend print save as pdf

Related Stories

Protein identified that plays role in blood flow

Sep 18, 2008

For years, researchers have known that high blood pressure causes blood vessels to contract and low blood pressure causes blood vessels to relax. Until recently, however, researchers did not have the tools to determine the ...

How blood flow dictates gene expression

Dec 20, 2006

Researchers at the University of Pennsylvania School of Medicine have pinpointed a key regulatory protein that translates blood flow into gene expression. The investigators showed that in a model of mouse embryonic ...

Need microRNA processing? Get Smad

Jun 11, 2008

Researchers at Tufts University School of Medicine and Tufts Medical Center have found that Smad proteins regulate microRNA (miRNA) processing. Understanding the role of Smad proteins enables researchers to investigate abnormal ...

Recommended for you

Jumping hurdles in the RNA world

Nov 21, 2014

Astrobiologists have shown that the formation of RNA from prebiotic reactions may not be as problematic as scientists once thought.

New computer model sets new precedent in drug discovery

Nov 18, 2014

A major challenge faced by the pharmaceutical industry has been how to rationally design and select protein molecules to create effective biologic drug therapies while reducing unintended side effects - a challenge that has ...

Finding new ways to make drugs

Nov 18, 2014

Chemists have developed a revolutionary new way to manufacture natural chemicals and used it to assemble a scarce anti-inflammatory drug with potential to treat cancer and malaria.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.