Does new swine flu virus kill by causing a 'cytokine storm'?

May 05, 2009

The swine flu outbreak that began in Mexico and continues to spread around the globe may be particularly dangerous for young, otherwise healthy adults because it contains genetic components of the H5N1 avian influenza virus, which can induce a "cytokine storm," in which a patient's hyper-activated immune system causes potentially fatal damage to the lungs. Research studies and review articles exploring the regulation of cytokine responses in the lung and how infection-related dysregulation can cause a cytokine storm have been published in Viral Immunology, a peer-reviewed journal published by Mary Ann Liebert, Inc.

A cytokine storm occurs when the body's immune system over-reacts to an intruder, such as a virus, by producing high levels of cytokines, which are signaling chemicals that help mobilize immune cells capable of removing infectious agents from the body. When too many cytokines are produced, they can stimulate an in which the accumulation of immune cells and fluid at the site of infection may prevent affected tissues and organs such as the lungs from functioning properly and may even cause death.

avian influenza virus—parts of which are present in the Mexican H1N1 swine flu virus causing the current outbreak—tend to cause an unusually high proportion of deaths among healthy young adults with well-functioning immune systems who become infected, most likely due to this cytokine storm phenomenon. The Spanish influenza pandemic of 1918, for example, was particularly deadly for young healthy adults.

David L. Woodland, PhD, Editor-in Chief of Viral Immunology, and President and Director of the Trudeau Institute, Inc. (Saranac Lake, NY), emphasizes that much is still not known about the current and the human/avian combination virus causing it. "We do not know how long ago this emerged, how deadly it is, whether it has pandemic potential, how the severity of infection relates to patient age, and why some infected patients die—whether a cytokine storm is responsible for these deaths," says Woodland.

What we do know, he adds, is that some H1N1 viruses have pandemic potential and that historical evidence supports the possibility that young healthy adults may be especially susceptible to more severe infection and poor outcomes due to the ability of a strong to initiate a cytokine storm.

More information: www.liebertpub.com/vim

Source: Mary Ann Liebert, Inc.

Explore further: Secret of tetanus toxicity offers new way to treat motor neuron disease

add to favorites email to friend print save as pdf

Related Stories

Virus' invasion sets off battle inside the body

May 01, 2009

Like a sleeper agent, the flu virus causes its damage from within, turning an organism's cells against itself. A single virus can hijack a healthy cell and transform it into a virus factory, making thousands of copies in ...

Your genes may hold key to how sick you get from the flu

Nov 03, 2006

With lessons from the 1918 flu pandemic in the rearview mirror and the avian flu a looming obstacle in the road ahead, researchers from Southern Illinois University School of Medicine are trying to understand why a flu virus ...

Recommended for you

Stroke damage mechanism identified

22 hours ago

Researchers have discovered a mechanism linked to the brain damage often suffered by stroke victims—and are now searching for drugs to block it.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.