New noninvasive liver fibrosis index reduces need for biopsies in children

May 01, 2009

A new non-invasive diagnostic index has been developed that may be used in tertiary care to rule in liver fibrosis in children with non-alcoholic fatty liver disease (NAFLD). The 'Pediatric NAFLD Fibrosis Index' (PNFI), described in the open access journal BMC Medicine, uses age, waist circumference and triglycerides to predict the presence of fibrosis.

Dr Valerio Nobili, from the Pediatric Hospital IRCCS "Bambino Gesů", Rome, worked a team of researchers including Dr Giorgio Bedogni and Professor Claudio Tiribelli to assess the factors that were associated with fibrosis in 203 children treated at the hospital's Liver Unit. Nobili said, "Diagnosis of liver fibrosis is currently based on liver biopsy. However, this is invasive and limited by the hazard and discomfort to the patient. Thus, there is a recognized need for less invasive strategies to identify the minority of NAFLD patients with liver fibrosis".

NAFLD is a highly prevalent and potentially very serious complication of childhood obesity. The early identification of fibrosis is particularly important in children as it may help prevent the development of liver disease in adulthood. The authors' evaluation of the ability of selected clinical features and laboratory exams to predict liver fibrosis in children with NAFLD revealed that by inputting a child's age, waist circumference and triglyceride levels into a relatively simple equation, it was possible to gain a useful indication of the likelihood of fibrosis.

Nobili concludes, "The use of non-invasive, reliable tests for this booming condition is important for children and adults and this is why we invested our expertise in the field of NAFLD into this original and important study".

More information: The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in with non-alcoholic fatty , Valerio Nobili, Anna Alisi, Andrea Vania, Claudio Tiribelli, Andrea Pietrobattista and Giorgio Bedogni, BMC Medicine (in press), http://www.biomedcentral.com/bmcmed/

Source: BioMed Central (news : web)

Explore further: Nigeria death shows Ebola can spread by air travel

add to favorites email to friend print save as pdf

Related Stories

Noninvasive ways to assess liver disease

Feb 02, 2008

Two new studies examine non-invasive ways to determine liver fibrosis and cirrhosis. An enhanced version of the Original European Liver Fibrosis panel was found to have good diagnostic accuracy for fibrosis in patients with ...

Noninvasive tests for cirrhosis may help to avoid liver biopsy

Oct 01, 2007

Newer ultrasound and magnetic resonance (MR) imaging tests yield encouraging initial results in diagnosing fibrosis (scarring) and cirrhosis of the liver, according to three studies in the October issue of the journal Clinical Ga ...

Recommended for you

Nigeria death shows Ebola can spread by air travel

10 hours ago

(AP)—Nigerian health authorities raced to stop the spread of Ebola on Saturday after a man sick with one of the world's deadliest diseases brought it by plane to Lagos, Africa's largest city with 21 million ...

Trial in salmonella outbreak to start in Georgia

10 hours ago

(AP)—Three people accused of scheming to manufacture and ship salmonella-tainted peanuts that killed nine people and sickened more than 700 are set to go to trial this week in Georgia.

Remote tribe members enter another village, catch flu

18 hours ago

Advocates for indigenous tribes are worried over incidents last month when some members of one of the last uncontacted tribes in the Peru/Brazil region, across borders, left their home in Peru and entered ...

Nigeria on red alert after first Ebola death

Jul 26, 2014

Nigeria was on alert against the possible spread of Ebola on Saturday, a day after the first confirmed death from the virus in Lagos, Africa's biggest city and the country's financial capital.

User comments : 0