New mediator of smoking recruits

Apr 24, 2009

Current research suggests that smoking increases the production of osteopontin in the lungs, which contributes to the development of smoking-related lung disease. The related report by Prasse et al, "Essential role of osteopontin in smoking-related interstitial lung diseases," appears in the May 2009 issue of The American Journal of Pathology.

Nearly one billion people worldwide smoke products. Long-term exposure to compounds found in smoke can lead to both cardiovascular and . Although lung exposure to leads to immune cell recruitment and tissue fibrosis, how cigarette smoke causes these changes is largely unknown.

To determine if osteopontin, a molecule that attracts immune cells, mediates cell recruitment in smokers, Prasse et al compared osteopontin levels from smokers with different types of lung diseases, healthy smokers, and healthy non-smokers. They found high levels of osteopontin expression in patients with interstitial lung disease, whereas healthy smokers had lower levels, and healthy non-smokers produced no osteopontin. Osteopontin expression could be stimulated directly by nicotine treatment. In addition, expressing osteopontin in rat lung resulted in recruitment of , resulting in symptoms similar to smoking-related interstitial lung diseases. These results indicate that osteopontin may be pathogenic in smoking-initiated lung disease.

The article from Prasse et al "suggest[s] that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production]." Osteopontin and cellular receptors for nicotine may therefore be new targets for treating smoking related lung disease.

More information: Prasse A, Stahl M, Schulz G, Kayser G, Qang L, Ask K, Yalcintepe J, Kirschbaum A, Bargagli E, Zissel G, Kolb M, Müller-Quernheim J, Weiss JM, Renkl AC: Essential role of osteopontin in smoking-related interstitial lung diseases. Am J Pathol 2009 174: 1683-1691

Source: (news : web)

Explore further: Study recommends inmate immunity test

add to favorites email to friend print save as pdf

Related Stories

New discovery may help explain smoking-pancreatic cancer link

Apr 14, 2008

If lung cancer and heart disease aren’t bad enough, cigarette smokers are also at higher risk for developing, among other things, pancreatic cancer. Now, researchers at the Kimmel Cancer Center at Jefferson in Philadelphia ...

Avoid the hookah and save your teeth

Nov 08, 2005

Researchers say smoking a hookah is becoming increasingly trendy item in Mediterranean restaurants, cafes and bars -- but it can damage your teeth.

Researchers identify another potential biomarker

Jan 13, 2009

Researchers from Boston University School of Medicine (BUSM) have demonstrated that a recently discovered class of molecule called microRNA (miRNAs), regulate the gene expression changes in airway cells that occur with smoking ...

Effects of smoking linked to accelerated aging protein

Feb 06, 2009

A University of Iowa study is apparently the first to make a connection between a rare, hereditary premature aging disease and cell damage that comes from smoking. The study results point to possible therapeutic targets for ...

Recommended for you

Study recommends inmate immunity test

Jul 25, 2014

(AP)—Federal experts are recommending that California test inmates for immunity to a sometimes fatal soil-borne fungus before incarcerating them at two Central Valley state prisons where the disease has killed nearly three ...

Down syndrome teens need support, health assessed

Jul 25, 2014

Young adults with Down syndrome experience a range of physical and mental health conditions over and above those commonly reported in children with the condition—and these health problems may significantly ...

Time out for exercise

Jul 25, 2014

University of Queensland researcher has found that restructuring our daily routine to include exercise can have unexpected effects on health.

User comments : 0