Commonly used ulcer drugs may offer treatment potential in Alzheimer's disease

Apr 22, 2009

In a new study, published in the May issue of Elsevier's Experimental Neurology, scientists at the University of British Columbia have discovered that drugs commonly used to treat ulcers have significant neuroprotective properties, which appear to be enhanced when used in combination with ibuprofen, a widely used anti-inflammatory drug.

"Our results show that inhibitors are also antiinflammatory agents. They open up an entirely new application for these drugs" said Dr. Sadayuki Hashioka, first author on the paper.

Proton pump inhibitors include lansoprazole and omeprazole. They are remarkably safe drugs which have so far been used only to treat ulcers and other conditions where there is excess gastric acidity. These include Helicobacter pylori infections and side effects from treatment with NSAIDs such as ibuprofen. The finding that they also have anti-inflammatory potential opens up the possibility of using these drugs in a variety of inflammatory conditions where NSAIDs are now used. There would be the double effect of protection from gastrointestinal side effects plus enhanced antiinflammatory activity.

The researchers found that when human , or human monocytic THP-1 cells, were exposed in vitro to the proton pump inhibitors, their secretions became less toxic towards human neuroblastoma cells. In addition, they found that these drugs acted synergistically with ibuprofen, a very widely used antiinflammatory agent. To confirm that the proton pump inhibitors were acting to inhibit inflammation, they found that lansoprazole and omeprazole reduced the secretion from THP-1 cells of the inflammatory cytokine tumor necrosis factor alpha.

Dr. Patrick McGeer, senior investigator on the UBC team, commented "Many epidemiological studies have revealed that individuals on long term treatment with ibuprofen are relatively spared from Alzheimer disease. Our investigation indicates that individuals taking lansoprezole or omeprazole in addition to ibuprofen might be getting even greater protection. It also suggests that a clinical trial of a combination of ibuprofen and a proton pump inhibitor might be effective for those already suffering from Alzheimer disease".

Epidemiological studies might show a sparing effect of Alzheimer disease through the use of proton pump inhibitors alone".

More information: The full article is "Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity", Experimental Neurology, Volume 217, Issue 1, pp. 177-183, available online 16 April 2009. Sadayuki Hashioka, Andis Klegeris, Patrick L. McGeer doi:10.1016/j.expneurol.2009.02.002, www.elsevier.com/locate/yexnr

Source: Elsevier

Explore further: Study links enzyme to autistic behaviors

add to favorites email to friend print save as pdf

Related Stories

Proton pump inhibitors increase risk of bone fractures

Aug 12, 2008

Patients who use proton pump inhibitors for 7 or more years to treat reflux, peptic ulcers and other conditions are at greater risk of osteoporosis-related fractures, according to this large observational study of 15,792 ...

Ibuprofen linked to reduced risk of Alzheimer's disease

May 05, 2008

Long-term use of ibuprofen and other drugs commonly used for aches and pains was associated with a lower risk of Alzheimer’s disease, according to a study published in the May 6, 2008, issue of Neurology, the medical journa ...

Ibuprofen puts high risk cardiac patients at risk

Apr 05, 2007

Doctors who treat the painful condition of osteoarthritis in patients with increased cardiovascular risk need to be cautious. A team lead by researchers at Mount Sinai School of Medicine, are the first to study outcomes in ...

Recommended for you

Study links enzyme to autistic behaviors

19 hours ago

Fragile X syndrome (FXS) is a genetic disorder that causes obsessive-compulsive and repetitive behaviors, and other behaviors on the autistic spectrum, as well as cognitive deficits. It is the most common ...

A new cause of mental disease?

Jul 23, 2014

Astrocytes, the cells that make the background of the brain and support neurons, might be behind mental disorders such as depression and schizophrenia, according to new research by a Portuguese team from ...

Molecular basis of age-related memory loss explained

Jul 22, 2014

From telephone numbers to foreign vocabulary, our brains hold a seemingly endless supply of information. However, as we are getting older, our ability to learn and remember new things declines. A team of ...

The neurochemistry of addiction

Jul 22, 2014

We've all heard the term "addictive personality," and many of us know individuals who are consistently more likely to take the extra drink or pill that puts them over the edge. But the specific balance of ...

User comments : 0