'Smart bomb' drug delivery may increase effectiveness

Apr 21, 2009

Researchers may have found a way to combine imaging with chemotherapy in a single agent for the treatment of prostate cancer, according to data presented at the American Association for Cancer Research 100th Annual Meeting 2009.

"It's like a smart bomb, to use a military analogy," said John P. Sedelaar, Ph.D., M.D., a postdoctoral research fellow at Johns Hopkins University. "By retooling agents, we may be able to get more accurate treatment monitoring and follow-up."

Sedelaar said current clinical practice uses multimodality MRI to examine the urological system for diagnosing . This tool, however, is mostly thought of as a prostate imaging method, rather than a prostate cancer imaging method.

"An increasing number of patients have minimal prostate cancer, and opt for either very focused treatment or the watchful waiting approach," said Sedelaar. "In this environment, the need for an accurate imaging tool is paramount."

Sedelaar and colleagues designed two imaging drugs: a PSMA and a PSA-activated pro-drug. These agents are therapeutic drugs that are modified by adding a tyrosine ring for imaging.

Following administration into laboratory mice, researchers noted a measureable reduction in .

Experiments also showed that the imaging pro-drugs were cleaved and activated by PSMA or PSA, suggesting their viability as a prostate cancer imaging modality.

"Unfortunately, next to clear tumor uptake there was also uptake into liver and kidney organs. Further experiments will have to address that problem," said Sedelaar.

Source: American Association for Cancer Research (news : web)

Explore further: Needs of Maori a priority to address poor stomach cancer survival - researchers

add to favorites email to friend print save as pdf

Related Stories

Men who take aspirin have significantly lower PSA levels

Nov 16, 2008

The use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is significantly associated with lower PSA levels, especially among men with prostate cancer, say researchers at Vanderbilt University.

Pomegranate Could Fight Cancer

Sep 24, 2007

Researchers in California are reporting new evidence explaining pomegranate juice’s mysterious beneficial effects in fighting prostate cancer. In a study scheduled for the Sept. 19 issue of ACS’ Journal of ...

MRI findings help forecast prostate cancer prognosis

Mar 25, 2008

Magnetic resonance imaging (MRI) findings in patients about to undergo radiation therapy for prostate cancer can help predict the likelihood that the cancer will return and spread post-treatment, according to a new study ...

Recommended for you

How 'wriggling' skin cancer cells go on the move

1 hour ago

(Medical Xpress)—Scientists at King's College London have discovered a new way that melanoma skin cancer cells can invade healthy tissue and spread round the body, according to research published in Nature Co ...

Breast cancer imaging surgery world-first

2 hours ago

A world-first clinical trial to test new imaging technology that can scan tumours during breast cancer surgery has been launched at Guy's and St Thomas' NHS Foundation Trust in collaboration with King's College ...

User comments : 0