Do patients at risk for B-cell malignancy need antiviral treatment?

Apr 15, 2009

Some studies have shown that a relationship of hepatitis C (HCV) infection with type II mixed cryoglobulinemia exists. However the precise mechanism remains unclear.

A research article to be published on April 7, 2009 in the addresses this question. The research team led by Professor Fan from the Department of Infectious Disease of the People's Liberation Army 161 Hospital in Wuhan used IgH rearrangement and immunohistochemistry. Various research studies indicated a relationship between the B-cell clonality with non-Hodgkin lymphoma, and this article further investigates the risk for developing malignant lymphoproliferative disease in the HCV-infected patients with B-cell clonality in the liver.

Liver-infiltrating monoclonal B-cells were detected in the liver of 4 (10%) of 40 HCV-positive patients but were present in only 3 (0.37%) of 808 liver specimens with chronic HBV infection. Chi-square tesing showed the monoclonal B-cells infiltrating in the liver were more frequent in the HCV-infected patients (P=0.000).A clonal IgH rearrangement was detected in 5 (71.4%) of 7 liver biopsy specimens with monoclonal B-cells infiltration. In 2 of 5 patients with both a clonal B-cell expansion and monoclonal B-cells infiltration in the liver, a definite B-cell malignancy was finally diagnosed.

Recent reports have highlighted the importance of antiviral treatment in the HCV-infected patient with B-cell clonality in the liver. This is the first study to analyze the association of monoclonal B-cells infiltrating in the liver with the B-cell clonality. Furthermore, our follow up study showed that lymphoma developed more frequently in the patients who had monoclonal B-cells infiltration and B-cell proliferation in the liver. The presence of a B-cell clonality and monoclonal B-cells infiltrating in the liver may be useful for detecting patients at high risk for developing malignant lymphoproliferative disease. The study results suggest a strategy for antiviral treatment in patients at risk for B-cell malignancy.

More information: Fan HB, Zhu YF, Chen AS, Zhou MX, Yan FM, Ma XJ, Zhou H. B-cell clonality in the of virus-infected . World J Gastroenterol 2009; 15(13): 1636-1640, http://www.wjgnet.com/1007-9327/15/1636.asp

Source: World Journal of Gastroenterology (news : web)

Explore further: Texas hospital isolates patient for Ebola tests

add to favorites email to friend print save as pdf

Related Stories

Improved culture system for hepatitis C virus infection

Jul 16, 2008

A University of California, San Diego School of Medicine researcher has developed the first tissue culture of normal, human liver cells that can model infection with the Hepatitis C virus (HCV) and provide a realistic environment ...

Grapefruit compound may help combat hepatitis C infection

Feb 04, 2008

A compound that naturally occurs in grapefruit and other citrus fruits may be able to block the secretion of hepatitis C virus (HCV) from infected cells, a process required to maintain chronic infection. A team of researchers ...

Recommended for you

Families wait in agony for word on Ebola patients

2 hours ago

First the ring tone echoed outside the barbed-wire-topped walls of the Ebola clinic. Then came the wails of grief, as news spread that 31-year-old Rose Johnson was dead just days after she was brought here ...

China to open first high security bio laboratory

3 hours ago

China's first high-security biosafety laboratory will be ready for use by December, in a move hailed as a "crucial" moment in the fight against pathogens such as the Ebola virus, officials said Tuesday.

US Ebola labs, parts for clinic arrive in Liberia

4 hours ago

U.S. mobile Ebola labs should be up and running in Liberia this week, and American troops have broken ground for a field hospital, as the international community races to increase the ability to care for ...

Ebola-hit Liberia staring into the abyss

8 hours ago

With its collapsed health service, sick and poorly equipped security forces and broken economy, Ebola-hit Liberia finds itself on the brink of complete societal breakdown, experts warn.

User comments : 0