Vitamin D Deficiency Related to Increased Inflammation in Healthy Women

Apr 06, 2009

(PhysOrg.com) -- According to a recent study in the Archives of Internal Medicine, 75 percent of Americans do not get enough Vitamin D. Researchers have found that the deficiency may negatively impact immune function and cardiovascular health and increase cancer risk. Now, a University of Missouri nutritional sciences researcher has found that vitamin D deficiency is associated with inflammation, a negative response of the immune system, in healthy women.

Increased concentrations of TNF-α, an inflammatory marker, were found in women who had insufficient levels. This study is the first to find an inverse relationship between vitamin D levels and concentrations of TNF-α in a healthy, non-diseased population. This may explain the vitamin's role in the prevention and treatment of inflammatory diseases, including heart disease, multiple sclerosis and rheumatoid arthritis.

"The findings reveal that low vitamin D levels negatively impact and immune response, even in healthy women," said Catherine Peterson, assistant professor in the MU College of Human Environmental Sciences. "Increased inflammation normally is found in people with obesity or chronic diseases; a small decrease in vitamin D levels may aggravate symptoms in people who are sick."

The results support the need to re-examine the biological basis for determining the dietary reference intake (DRI) of vitamin D, Peterson said. The Institute of Medicine's DRI for vitamin D is 200 IU for people age 50 and younger and 400 IU for people 50 to 70 years old. The guidelines, created in 1997, are being revised to reflect new research, and Peterson is confident the DRI will be increased.

"Adequate vitamin D levels identified in this study are consistent with recent research that suggests the DRI should be increased," Peterson said. "To improve vitamin D status and achieve its related health benefits, most people should get at least 1000 IU of vitamin D per day. Sunlight is a readily-available, free source of vitamin D. Exposing 25 percent of the skin's surface area to 10 minutes of sunlight three days per week will maintain adequate levels in the majority of people; however, people with darkly-pigmented skin need more. Only a few foods contain vitamin D naturally, such as fatty fish; other sources are dietary supplements and vitamin-D-fortified foods, including milk and orange juice."

In future studies, Peterson will determine the effectiveness of Vitamin D in reducing disease symptoms and reducing blood glucose levels in diabetics. The study, "Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH) D concentrations in healthy women," was published in the July, 2008 issue of the Journal of Inflammation.

Provided by University of Missouri

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User comments : 7

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Roj
5 / 5 (1) Apr 06, 2009
The daily intake 1000IU of vitamin D does not consider toxicity levels for pregnant women at ~400IU daily.

Accidental poisonings of children have also occurred with a number of vitamins, most notably with large doses of fat soluble iron and vitamins A and D.

Small amounts of Drug-nutrient interactions can also be fatal with substances such as MAOI's.
Ashy
1 / 5 (1) Apr 07, 2009
Overdose of vitamin D is much more dangerous than deficiency of vitamin D. D-overdozing leads to chronical diseases of bones, heart, kidneys, ets.
TedHutchinson1
not rated yet Apr 14, 2009
"Risk assessment for vitamin D"
http://www.ajcn.o...l/85/1/6
Explains that up to 10,000iu/daily Vitamin D is a safe upper limit as adverse events have only been recorded above 200ng/mL or 500nmol/l.

The average female living around or above latitude 40 will require 5000iu/daily males 6000iu/d to achieve 150nmol/l 60ng the level associated with least chronic disease incidence.

To get up to the level associated with adverse events requires months and months of taking around 40,000iu/d.

Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe.
http://www.ncbi.n...19268496
explains the range of conditions that occur in the Vitamin D deficient and attempts to quantify the cost burden of vitamin d insufficiency.

A more accessible chart of the diseases associated with 25(OH)D levels below 56ng are set out here
http://www.grassr...2608.pdf

Grassrootshealth is a charity promoting knowledge of D3. The videos from the world's leading Vit d Scientists are all worth watching.
http://www.grassr...lth.net/
They also subsidize 25(OH)D testing.
http://www.grassr...lth.net/d-action
Ashy
1 / 5 (1) Apr 15, 2009
Do you think The American Journal of Clinical Nutrition will say something bad about synthetical Vit.D? I can't find there anything about Sulkovich's probe. This probe is necessary to diagnose lack of Vit.D. Human with Sulkovich's probe " " mustn't take Vit.D doses, and human with " " could be dye or at least become a chronic patient.

"May as well consult a butcher on the value of vegetarianism as a doctor on the worth of vaccination." - Bernard Shaw

I can add: and on the worth of pharmaceutical products.
Ashy
1 / 5 (1) Apr 15, 2009
First " " means "3 pluses", second " " means "4 pluses". Sorry, it was script's error.
Roj
not rated yet Apr 22, 2009
"Risk assessment for vitamin D"
http://www.ajcn.o...l/85/1/6

While study method & controls may be superior to prior efforts, the sample groups were carefully selected by authors reported to be employed by a vitamin and dietary supplement industry trade association.

Toxic interaction data appears carefully avoided with all but Calcium and Thyroid treatments. Whether all other drug interactions or synthetic-equivalents common to the environment are substantial or not, is omitting such data a typical embellishment of employed servants who conduct studies for their industry captains?
Roj
not rated yet Apr 22, 2009
The professional clinicians data set derives upper limits by omitting toxic interactions between Vit-D and other drugs such as Estrogen, common to Tofu, milk, & drinking water.
http://www.umm.ed...0995.htm