Journal retracts diabetes study published in 2000

Apr 01, 2009

(AP) -- A scientific journal is retracting a research paper published more than eight years ago that reported a gene therapy treatment had led to remission of Type 1 diabetes in rats and mice.

In its Thursday issue, Nature said the lead author of the paper - Hyun Chul Lee of Yonsei University in Seoul, South Korea - and two other authors asked for the retraction because they could not reproduce the experiment's results.

Another author maintains the results are still valid and did not join in the retraction request, the journal said. A fifth author is deceased.

In Type 1, or juvenile, , the body mistakenly attacks insulin-producing . Patients must inject themselves with to survive. The researchers reported eliminating the disease in rodents by slipping into them a man-made gene designed to produce an insulin-like chemical.

The authors wrote at the time that the approach might be useful for humans. But diabetes experts told The Associated Press in November 2000 that it wasn't clear the treatment would work in people.

---

On the Net:

Nature: http://www.nature.com/nature

©2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Explore further: Scientists find new calorie-burning switch in brown fat

add to favorites email to friend print save as pdf

Related Stories

Impaired fat-burning gene worsens diabetes

Feb 07, 2008

Researchers at the Swedish medical university Karolinska Institutet have in collaboration with researchers from Finland, China, Japan and the US discovered new cellular mechanisms that lead to in insulin resistance in people ...

Is there a relationship between sleep-wake rhythm and diabetes?

Jan 16, 2009

The gene mediates insulin secretion indirectly via the release of melatonin, which implicates a previously unknown relationship between the sleep-wake rhythm and the fasting glucose level. The finding could open up new possibilities ...

Recommended for you

Clues to curbing obesity found in neuronal 'sweet spot'

4 hours ago

Preventing weight gain, obesity, and ultimately diabetes could be as simple as keeping a nuclear receptor from being activated in a small part of the brain, according to a new study by Yale School of Medicine ...

Small RNAs in blood may reveal heart injury

13 hours ago

(Medical Xpress)—Like clues to a crime, specific molecules in the body can hint at exposure to toxins, infectious agents or even trauma, and so help doctors determine whether and how to treat a patient. ...

User comments : 0