Factors associated with decline in child kidney function identified

Mar 18, 2009

Characteristics associated with proteinuria—a predictor of decline in child kidney function—have been identified, according to a study appearing in the March 2009 issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that the level of kidney impairment, the cause of kidney disease, and race are linked to proteinuria—the presence of protein in the urine. The results provide new information regarding the importance of proteinuria and the factors associated with its development in the largest group of children with chronic kidney disease (CKD) ever studied.

In with CKD, proteinuria has not been studied extensively and researchers did not know what factors are linked to its presence. To better understand proteinuria in young patients, Craig Wong, MD, MPH (University of New Mexico) and his colleagues studied subjects enrolled in the Disease in Children (CKiD) cohort study, a trial designed to investigate the factors influencing the progression of CKD in children.

The researchers studied more than 400 patients who were aged 1 to 16 years and were seen at 43 pediatric nephrology centers across North America. Clinical tests revealed that proteinuria levels were higher in children with low glomerular filtration rates (an indication of low kidney function). Proteinuria also was associated with non-Caucasian race, which suggests that differences in proteinuria might be due to genetic or environmental factors. The investigators also found that proteinuria was associated with glomerular causes of CKD in which damage occurs in the glomeruli (filtering units inside the kidneys). Furthermore, among patients with glomerular causes of CKD, those who took renin-angiotensin system antagonizing drugs had lower levels of proteinuria compared with those who did not take these medications.

The findings from this study—that in children with CKD, proteinuria is associated with 1) low glomerular , 2) the underlying glomerular cause of CKD, and 3) African American race—will be useful for physicians as they strive to prevent kidney disease progression in young patients.

George J. Schwartz, MD (University of Rochester), a co-author of the study, says that "the CKiD study will enable us to directly examine the effect of proteinuria on the progression of CKD in children, because the design of this study specifies three longitudinal measurements of in each subject over five years of follow-up."

More information: The article, entitled "Association of Proteinuria with Race, Cause of Chronic Kidney Disease, and Glomerular Filtration Rate in the Chronic Kidney Disease in Children Study," will appear online at cjasn.asnjournals.org/ on March 18, 2009, doi 10.2215/CJN.01780408.

Source: American Society of Nephrology (news : web)

Explore further: Obama addresses West Africans on facts about Ebola

add to favorites email to friend print save as pdf

Related Stories

Low thyroid function common in chronic kidney disease

Jun 11, 2008

Many patients with chronic kidney disease (CKD) have mild reductions in thyroid function, or subclinical hypothyroidism—a condition that becomes more common as kidney function declines, according to a study in the September ...

Updated formula measures kidney function more accurately

Feb 24, 2009

Measuring kidney function in children can be expensive, time-consuming for clinicians, and tedious for children, who may be exposed to radioactivity and subjected to a large number of blood draws. A new calculation eliminates ...

Recommended for you

Obama addresses West Africans on facts about Ebola

7 hours ago

President Barack Obama urged West Africans on Tuesday to wear gloves and masks when caring for Ebola patients or burying anyone who died of the disease. He also discouraged the traditional burial practice ...

Gluten-free diet benefits asymptomatic EmA+ adults

7 hours ago

(HealthDay)—Asymptomatic individuals with endomysial antibodies (EmA) benefit from a gluten-free diet (GFD), according to a study published in the September issue of Gastroenterology.

Another US health worker infected with Ebola

7 hours ago

A third American health worker has tested positive for the Ebola virus while working with patients in West Africa, the Christian missionary group SIM said Tuesday.

UN implores all countries to help on Ebola

9 hours ago

The international group Doctor Without Borders warned Tuesday that the world is 'losing the battle' against Ebola, while U.N. officials implored all countries to quickly step up their response by contributing health experts ...

Travel restrictions could worsen Ebola crisis: experts

14 hours ago

Travel restrictions could worsen West Africa's Ebola epidemic, limiting medical and food supplies and keeping out much-needed doctors, virologists said Tuesday as the disease continued its deadly spread.

User comments : 0