Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases

Mar 05, 2009

An experimental procedure that dramatically strengthens stem cells' ability to regenerate damaged tissue could offer new hope to sufferers of muscle-wasting diseases such as myopathy and muscular dystrophy, according to researchers from the University of New South Wales (UNSW).

The world-first procedure has been successfully used to regrow muscles in a mouse model, but it could be applied to all tissue-based illnesses in humans such as in the liver, pancreas or brain, the researchers say.

The research team, which is based at UNSW and formerly from Sydney's Westmead Children's Hospital, adapted a technique currently being trialled in bone marrow transplantation. Adult stem cells are given a gene that makes them resistant to chemotherapy, which is used to clean out damaged cells and allow the new stem cells to take hold.

A paper detailing the breakthrough appears in the prestigious journal Stem Cells this week.

The ability of adult stem cells to regenerate whole tissues opens up a world of new possibilities for many human diseases, according to the lead authors of the paper, Professor Peter Gunning, Professor Edna Hardeman and Dr Antonio Lee, from UNSW's School of Medical Sciences.

"The beauty of this technique is that chemotherapy makes space for stem cells coming into muscle and also gives the stem cells an advantage over the locals. It's the first strategy that gives the good guys the edge in the battle to cure sick tissues," Professor Gunning said.

"What has been the realm of science fiction is looking more and more like the medicine of the future," he said.

The procedure solves one of the major hurdles involving stem cell therapy - getting the cells to survive for more than an hour or so after inserting them into damaged tissue.

"In muscle, most stem cells die in the first hour or are present in such low numbers that they are not much help," Professor Gunning said. "Until now, the new healthy cells had no advantage over the existing damaged tissue and were getting out-competed.

While trials of the procedure are at the pre-clinical stage, researchers are looking to launch human trials treating specific forms of muscular dystrophy such as oculopharyngeal dystrophy within the next three to five years.

Source: University of New South Wales

Explore further: Study reveals one reason brain tumors are more common in men

add to favorites email to friend print save as pdf

Related Stories

Lenovo's smart glasses prototype has battery at neck

1 hour ago

China's PC giant Lenovo last week offered a peek at its Google Glass-competing smart glass prototype, further details of which are to be announced in October. Lenovo's glasses prototype is not an extreme ...

Recommended for you

Clues to curbing obesity found in neuronal 'sweet spot'

7 hours ago

Preventing weight gain, obesity, and ultimately diabetes could be as simple as keeping a nuclear receptor from being activated in a small part of the brain, according to a new study by Yale School of Medicine ...

Small RNAs in blood may reveal heart injury

17 hours ago

(Medical Xpress)—Like clues to a crime, specific molecules in the body can hint at exposure to toxins, infectious agents or even trauma, and so help doctors determine whether and how to treat a patient. ...

User comments : 2

Adjust slider to filter visible comments by rank

Display comments: newest first

moj85
not rated yet Mar 05, 2009
dangerous - creating cells that are resistant to chemotherapy? This might come back to bite us in the butt..
jim444
not rated yet Jun 20, 2009
If your gonna die anyway..Id do it.

Does seem Stem Cells are getting closer into clinical being....it's clear we are very close to a major advancement.