High-flux hemodialysis prolongs survival in many patients with CKD

Feb 20, 2009

High-flux hemodialysis (which removes large toxins) reduces the risk of premature death in many patients with chronic kidney disease (CKD), according to a study appearing in the March 2009 issue of the Journal of the American Society Nephrology (JASN). The results suggest that this procedure could be beneficial for those with poor prognoses and those with diabetes.

In patients with CKD, toxins accumulate in the blood because the kidneys lose their ability to eliminate these substances sufficiently. CKD patients undergo either high-flux or low-flux hemodialysis to clear these toxins from the body (high-flux membranes have larger pores that allow for the removal of toxins of greater molecular size). While epidemiological studies have indicated that treatment with high-flux hemodialysis improved survival, the true potential of this treatment on prolonging life has not been clearly determined.

Francesco Locatelli, MD (A. Manzoni Hospital, Lecco, Italy), and his colleagues in eight European countries conducted a clinical trial to investigate the effect of high-flux hemodialysis on patient survival. In a randomized clinical trial called the Membrane Permeability Outcome (MPO) study, they enrolled 738 hemodialysis patients and assigned them to either low-flux or high-flux hemodialysis. Patients were followed for 3 to 7.5 years; in the entire study group the researchers did not detect a significant survival benefit with either high-flux or low-flux hemodialysis, but the use of high-flux membranes conferred a significant survival benefit in higher-risk patients. In addition, patients with diabetes showed a survival benefit with high-flux dialysis.

These findings could lead to potentially valuable clinical benefits for patients with CKD. However, because the benefits in diabetic patients were found only after a post-hoc analysis of the data, Dr. Locatelli's team noted that their results in diabetic patients need to be confirmed by other clinical trials.

More information: The article, entitled "Effect of Membrane Permeability on Survival of Hemodialysis Patients," is currently online, doi 10.1681/ASN.2008060590.

Source: American Society of Nephrology

Explore further: Flu winds down as FDA aims for better vaccine next winter

add to favorites email to friend print save as pdf

Related Stories

Why your laptop battery won't kill you

3 hours ago

News on Tuesday that major U.S. airlines are no longer going to ship powerful lithium-ion batteries might lead some to fret about the safety of their personal electronic devices.

Visa, MasterCard moving into mobile pay in Africa

3 hours ago

Americans may just be getting used to mobile pay, but consumers in many African countries have been paying with their phones for years. Now payment processors Visa and MasterCard want to get a slice of that market, and are ...

Recommended for you

Second LA hospital issues alert over 'superbug'

9 hours ago

The Cedars-Sinai Medical Center may have unwittingly infected nearly 70 patients with a treatment-resistant superbug, it said Wednesday, becoming the second Los Angeles hospital to issue an alert.

DR Congo cholera cases top 1,500, 35 dead: UN

13 hours ago

A cholera outbreak in the Democratic Republic of Congo has infected 1,500 people and caused 35 deaths in less than two months, the United Nations said on Wednesday.

UTMB collaboration results in rapid Ebola test

22 hours ago

University of Texas Medical Branch researchers who helped assess the effectiveness of a new rapid test kit to diagnose Ebola learned this week it has received emergency use authorization from the Food and ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.