Researchers find parental dementia may lead

Feb 19, 2009

People who have parents diagnosed with Alzheimer's disease or dementia perform less well on formal memory testing when compared to people of the same age whose parents never developed Alzheimer's disease or other dementia. This is true even in middle-aged persons who do not have a diagnosis of clinical stroke or dementia, according to a Boston University School of Medicine (BUSM) study. This study has been selected to be presented at a Plenary Session at the American Academy of Neurology's 61st Annual Meeting in Seattle, Wash from April 25 - May 2.

Researchers from the Framingham Heart Study (FHS) are following three generations of participants to study the risk factors and earliest biomarkers of Alzheimer's disease, stroke and other cardiac and neurological diseases. The first generation has been followed since 1948. Since both the parental and offspring generation are enrolled as study participants, researchers could accurately identify which parents did or did not develop Alzheimer's disease or other dementia in their lifetime.

For this study, researchers studied 715 participants (372 women, 343 men) belonging to the second generation of FHS (average age 59) using standardized cognitive tests and MRI brain scans. One group of 282 persons had one or both parents fulfilling standardized criteria for a diagnosis of dementia, the other group of 433 persons had parents who were known to be free of dementia. The scientists also tested all these individuals for a gene thought to be a strong risk factor for dementia, called the ApoE ε4 gene.

Among persons who were carriers of the ApoE ε4 gene, those who had parents with Alzheimer's disease or other dementia scored significantly worse on tests of verbal memory and visual memory than persons who did not have parents with Alzheimer's dementia.

"Parental dementia and Alzheimer's disease were significantly associated with poorer performance in verbal and visual memory tasks," said senior author Sudha Seshadri, MD, associate professor of neurology and co-director of the Medical Education for Neurology Residency Program at Boston University School of Medicine.

Researchers further concluded that the result in persons with parents who have Alzheimer's disease is equivalent to approximately 15 years of brain aging. The effect was largely limited to those study participants who have the ApoE ε4 gene, which supports the idea that the gene is probably at least partially responsible for the transmission of Alzheimer's disease risk between generations.

Source: Boston University

Explore further: Travel restrictions could worsen Ebola crisis: experts

add to favorites email to friend print save as pdf

Related Stories

Having a parent with dementia may affect memory in midlife

Feb 18, 2009

People who have parents diagnosed with Alzheimer's disease or dementia may be more likely to have memory loss themselves in middle age, according to a study released today that will be presented at the American Academy of ...

Research casts doubt on theory of cause of chronic fatigue

Mar 21, 2011

A high-profile scientific paper that gave enormous hope to patients diagnosed with chronic fatigue syndrome, and even prompted some to begin taking potent anti-HIV drugs, has been largely discredited by subsequent research.

Recommended for you

Travel restrictions could worsen Ebola crisis: experts

2 hours ago

Travel restrictions could worsen West Africa's Ebola epidemic, limiting medical and food supplies and keeping out much-needed doctors, virologists said Tuesday as the disease continued its deadly spread.

World 'losing battle' to contain Ebola: MSF (Update)

3 hours ago

International medical agency Medecins sans Frontieres said Tuesday the world was "losing the battle" to contain Ebola as the United Nations warned of severe food shortages in the hardest-hit countries.

Mutating Ebola viruses not as scary as evolving ones

3 hours ago

My social media accounts today are cluttered with stories about "mutating" Ebola viruses. The usually excellent ScienceAlert, for example, rather breathlessly informs us "The Ebola virus is mutating faster in humans than in animal hosts ...

War between bacteria and phages benefits humans

4 hours ago

In the battle between our immune systems and cholera bacteria, humans may have an unknown ally in bacteria-killing viruses known as phages. In a new study, researchers from Tufts University, Massachusetts ...

Ebola kills 31 people in DR Congo: WHO

6 hours ago

An outbreak of the Ebola virus in the Democratic Republic of Congo has killed 31 people and the epidemic remains contained in a remote northwestern region, UN the World Health Organization (WHO) said Tuesday.

User comments : 0