I feel your pain: Neural mechanisms of empathy

Jan 28, 2009

Is it possible to share a pain that you observe in another but have never actually experienced yourself? A new study uses a sophisticated brain-imaging technique to try and answer this question. The research, published by Cell Press in the January 29th issue of the journal Neuron, provides insight into brain mechanisms involved in empathy.

Brain-imaging studies have shown similar patterns of brain activity when subjects feel their own emotions or observe the same emotions in others. It has been suggested that a person who has never experienced a specific feeling would have a difficult time directly empathizing with a person through a "mirror matching" mechanism that requires previous experience and would instead have to rely on a higher inferential processes called "perspective taking."

"Patients with congenital insensitivity to pain (CIP) offer a unique opportunity to test this model of empathy by exploring how the lack of self-pain representation might influence the perception of others' pain," explains lead author Dr. Nicolas Danziger from the Department of Clinical Neurophysiology and Pain Center at the Pitie-Salpetriere in Paris, France.

Dr. Danziger and colleagues had previously shown that CIP patients underestimated the pain of others when emotional cues were lacking and, in contrast with control subjects, the ability to fully acknowledge others' pain depended on a capacity for empathy. In this study, the researchers used functional magnetic resonance imaging (fMRI) to compare brain activation patterns in CIP patients and controls who were asked to imagine the feelings of a person in a photo that showed body parts in painful situations or facial expressions of pain.

CIP patients showed decreased fMRI activation of visual regions, a result indicative of their reduced emotional arousal to the view of others' pain. On the other hand, in the CIP patients but not the controls, the capacity for empathy strongly predicted activation of key midline brain structures involved in processes linked to inferring the emotional states of others.

These results suggest that in the absence of functional resonance mechanisms shaped by personal pain experiences, CIP patients might rely crucially on their empathetic abilities to imagine the pain of others, with activation of midline brain structures being the neural signature of this cognitive-emotional process.

"Our findings underline the major role of midline structures in emotional perspective taking and in the ability to understand someone else's feelings despite the lack of any previous personal experience of it—an empathetic challenge frequently raised during human social interactions," concludes Dr. Danziger.

Source: Cell Press

Explore further: Secret of tetanus toxicity offers new way to treat motor neuron disease

add to favorites email to friend print save as pdf

Related Stories

Audi to develop Tesla Model S all-electric rival

5 hours ago

The Tesla Model S has a rival. Audi is to develop all-electric family car. This is to be a family car that will offer an all-electric range of 280 miles (450 kilometers), according to Auto Express, which ...

New largest number factored on a quantum device is 56,153

6 hours ago

(Phys.org)—Researchers have set a new record for the quantum factorization of the largest number to date, 56,153, smashing the previous record of 143 that was set in 2012. They have shown that the exact same room-t ...

Recommended for you

Stroke damage mechanism identified

Nov 27, 2014

Researchers have discovered a mechanism linked to the brain damage often suffered by stroke victims—and are now searching for drugs to block it.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.