Baffling the body into accepting transplants

Jan 21, 2009

An unexpected discovery made by a Sydney scientist has potential to alter the body's response to anything it perceives as not 'self', such as a tissue or organ transplant.

Stacey Walters, an immunology researcher at the Garvan Institute of Medical Research, has found that by greatly boosting the levels of the hormone BAFF in mice, it is possible to alter their immune systems so that they will accept tissue transplants without the need for any immunosuppression.

The findings have just been published in the Journal of Immunology.

Specifically, Stacey has found that mice genetically engineered to produce large amounts of BAFF (B cell activating factor), don't reject transplants.

She has shown that increased numbers of B cells (caused by boosted BAFF levels) in turn stimulate the production of T regulatory cells, which then control T cells, the body's killer cells.

The surprising thing about the results is that B cells, which make antibodies, were not known to have any role in the production of T regulatory cells. Nor would it have been thought possible for them to influence the body's response to a transplant, which has been considered a function of T cells only.

"In normal situations, something has to turn the immune system off once your body's fought an invader, such as a virus. It's the T regulatory cells that come in and say 'enough's enough'," Stacey explained.

Just to make sure it was the B cells that were provoking the changes, Stacey repeated her experiments on a mouse in which B cells were genetically knocked out, but high BAFF levels preserved. She found that when there are no B cells, normal allograft rejection occurs.

Stacey's results give us insight into previously unknown interrelationships between various classes of immune cells. Manipulating these relationships may offer a way of preserving organ grafts in the future without the need for toxic immunosuppressive drugs.

Source: Research Australia

Explore further: Newly discovered hormone mimics the effects of exercise

add to favorites email to friend print save as pdf

Related Stories

Why your laptop battery won't kill you

6 hours ago

News on Tuesday that major U.S. airlines are no longer going to ship powerful lithium-ion batteries might lead some to fret about the safety of their personal electronic devices.

Visa, MasterCard moving into mobile pay in Africa

6 hours ago

Americans may just be getting used to mobile pay, but consumers in many African countries have been paying with their phones for years. Now payment processors Visa and MasterCard want to get a slice of that market, and are ...

Recommended for you

Newly discovered hormone mimics the effects of exercise

7 hours ago

Scientists at the USC Leonard Davis School of Gerontology have discovered a new hormone that fights the weight gain caused by a high-fat Western diet and normalizes the metabolism - effects commonly associated ...

Highly sensitive detection of malaria parasites

9 hours ago

New assays can detect malaria parasites in human blood at very low levels and might be helpful in the campaign to eradicate malaria, reports a study published this week in PLOS Medicine. An international team l ...

How fat breakdown contributes to insulin resistance

15 hours ago

New research from the University of Virginia School of Medicine has shed light on how chronic stress and obesity may contribute to type 2 diabetes. The findings point the finger at an unexpected biological perpetrator – ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.