New family of antibacterial agents uncovered

Jan 15, 2009

As bacteria resistant to commonly used antibiotics continue to increase in number, scientists keep searching for new sources of drugs. In this week's JBC, one potential new bactericide has been found in the tiny freshwater animal Hydra.

The protein identified by Joachim Grötzinger, Thomas Bosch and colleagues at the University of Kiel, hydramacin-1, is unusual (and also clinically valuable) as it shares virtually no similarity with any other known antibacterial proteins except for two antimicrobials found in another ancient animal, the leech.

Hydramacin proved to be extremely effective though; in a series of laboratory experiments, this protein could kill a wide range of both Gram-positive and Gram-negative bacteria, including clinically-isolated drug-resistant strains like Klebsiella oxytoca (a common cause of nosocomial infections). Hydramacin works by sticking to the bacterial surface, promoting the clumping of nearby bacteria, then disrupting the bacterial membrane.

Grötzinger and his team also determined the 3-D shape of hydramacin-1, which revealed that it most closely resembled a superfamily of proteins found in scorpion venom; within this large group, they propose that hydramacin and the two leech proteins are members of a newly designated family called the macins.

Paper: "Hydramacin-1, Structure and Antibacterial Activity of a Protein from the Basal Metazoan Hydra" by Sascha Jung, Andrew J. Dingley, René Augustin, Friederike Anton-Erxleben, Mareike Stanisak, Christoph Gelhaus, Thomas Gutsmann, Malte U. Hammer, Rainer Podschun, Alexandre M. J. J. Bonvin, Matthias Leippe, Thomas C. G. Bosch, and Joachim Grötzinger. Article link: www.jbc.org/cgi/content/full/284/3/1896

Source: American Society for Biochemistry and Molecular Biology

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