Antibodies produced within joints in rheumatoid arthritis

Jan 13, 2009

Antibodies produced within the joints themselves may be responsible for joint damage in rheumatoid arthritis, according to new research published in PLoS Medicine.

Studying joint biopsies from people with rheumatoid arthritis, Costantino Pitzalis of Barts and the London School of Medicine and colleagues found that tiny structures in the joint lining mimic key functions of antibody-producing lymph nodes, and can support the production of specific antibodies that may play a role in joint destruction.

They found that these processes continued after joint tissue bearing the lymphoid structures was transplanted into mice without immune systems of their own, indicating that potentially destructive antibody production within joints can proceed independently of the body's lymph nodes.

Citation: Humby F, Bombardieri M, Manzo A, Kelly S, Blades MC, et al. (2009) Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med 6(1): e1. doi:10.1371/journal.pmed.0060001
medicine.plosjournals.org/perl… journal.pmed.0060001

Source: Public Library of Science

Explore further: The human parasite Leishmania is a probiotic for the fly that carries it

add to favorites email to friend print save as pdf

Related Stories

Curry spice could offer treatment hope for tendinitis

Aug 09, 2011

(PhysOrg.com) -- A derivative of a common culinary spice found in Indian curries could offer a new treatment hope for sufferers of the painful condition tendinitis, an international team of researchers has shown.

Recommended for you

Diseases of another kind

9 hours ago

The drought that has the entire country in its grip is affecting more than the color of people's lawns. It may also be responsible for the proliferation of a heat-loving amoeba commonly found in warm freshwater bodies, such ...

User comments : 0