Pre-existing diabetes for persons diagnosed with cancer associated with increased risk of death

Dec 16, 2008

Patients with diabetes at the time of a cancer diagnosis have an increased risk of death compared to patients without diabetes, according to a meta-analysis of studies reported in the December 17 issue of JAMA.

Approximately 20 million Americans have diabetes mellitus, which is about 7 percent of the U.S. adult population. Diabetes mellitus appears to be a risk factor for some cancers, but the effect of pre-existing diabetes on all-cause death in newly diagnosed cancer patients is less clear, according to background information in the article.

Bethany B. Barone, Sc.M., of the Johns Hopkins Bloomberg School of Public Health, Baltimore, and colleagues conducted a meta-analysis to examine the association of pre-existing diabetes with long-term, all-cause death in cancer patients. The researchers identified 48 articles that met criteria for the study, including 23 articles for which data could be included in the meta-analysis.

The meta-analysis (of these 23 studies) indicated that pre-existing diabetes was associated with an increase in all-cause death following cancer diagnosis, compared with individuals with normal glucose levels, across all cancer types. Additional analyses by type of cancer showed that pre-existing diabetes was significantly associated with increased long-term, all-cause death for cancers of the endometrium, breast, and colorectum. Diabetes was associated with a nonsignificant increase in risk in prostate, gastric, hepatocellular, lung and pancreatic cancer.

"Future research should determine the relative importance of different pathways to diabetes-related mortality risk. If a clinical or biological interaction between diabetes and cancer care is confirmed, subsequent trials should test whether improvements in diabetes care for patients with newly diagnosed cancer might reduce long-term mortality," the authors conclude.

Publication: JAMA. 2008;300[23]:2754-2764.

Source: JAMA and Archives Journals

Explore further: Researchers find chemotherapy after bladder cancer surgery improved survival

add to favorites email to friend print save as pdf

Related Stories

Spacewalking astronauts finish extensive, trick cable job

9 hours ago

(AP)—Spacewalking astronauts successfully completed a three-day cable job outside the International Space Station on Sunday, routing several-hundred feet of power and data lines for new crew capsules commissioned ...

IOC defends Rio legacy amid green protests

12 hours ago

Ecological protests on Saturday dogged the final day of an International Olympic Committee executive board meeting in Rio as green campaigners slated the choice of a nature reserve to hold the golf event ...

Recommended for you

US women's awareness of breast density varies

29 minutes ago

Disparities in the level of awareness and knowledge of breast density exist among U.S. women, according to the results of a Mayo Clinic study published in the Journal of Clinical Oncology.

Study shows why some brain cancers resist treatment

43 minutes ago

Scientists at The University of Texas MD Anderson Cancer Center may have discovered why some brain cancer patients develop resistance to standard treatments including radiation and the chemotherapy agent temozolomide.

Researchers identify genes responsible for lung tumors

2 hours ago

The lung transcription factor Nkx2-1 is an important gene regulating lung formation and normal respiratory functions after birth. Alterations in the expression of this transcription factor can lead to diseases such as lung ...

Lycopene may ward off kidney cancer in older women

4 hours ago

A higher intake by postmenopausal women of the natural antioxidant lycopene, found in foods like tomatoes, watermelon and papaya, may lower the risk of renal cell carcinoma, a type of kidney cancer.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.