Fractional dose of scarce meningitis vaccine may be effective in outbreak control

Dec 05, 2008

One fifth of the standard dose of a commonly used meningitis vaccine may be as effective as using the full dose. This new finding should allow scarce vaccine resources to be stretched further, especially during epidemics in Africa.

In a study initiated by the Norwegian Institute of Public Health, together with Epicentre (the research arm of Doctors Without Borders/Médecins Sans Frontières), and Mbarara University of Science and Technology in Uganda, immune responses in patients receiving smaller doses of a meningitis vaccine were found to be comparable to a full dose.

In 2004, a randomized clinical trial of 750 healthy volunteers (2-19 years old) took place in Uganda. Their immune response, assessed by serum bactericidal activity (SBA), was measured for 1/5 and 1/10 doses compared to a full dose. SBA response and safety/tolerability using 1/5 dose were comparable to a full dose for three serogroups (A, Y, W135), but not a fourth (C).

The results have now been published in PLoS Neglected Tropical Diseases.

Source: Norwegian Institute of Public Health

Explore further: Research shows that bacteria survive longer in contact lens cleaning solution than thought

add to favorites email to friend print save as pdf

Related Stories

A digital version of you

Mar 12, 2014

When NASA's Mars Rover Opportunity sends a photograph of the alien landscape back to Earth, it relays the information as digital data, a series of ones and zeros that computers assemble into pictures that ...

UNICEF discloses vaccine prices for 1st time

May 29, 2011

UNICEF is for the first time publicizing what drugmakers charge it for vaccines, as the world's biggest buyer of lifesaving immunizations aims to spark price competition in the face of rising costs.

ActHIB vaccine recalled in Japan

Mar 11, 2011

Sanofi Pasteur and Daiichi Sankyo on Friday announced a recall of the ActHIB vaccine in Japan after an "unidentified substance" was found in two syringes.

US cable: Pfizer sought dirt on Nigerian official

Dec 10, 2010

(AP) -- Drug maker Pfizer Inc. hired investigators to uncover "corruption links" to Nigeria's embattled former attorney general in an attempt to stop federal cases over a 1996 drug study, according to a U.S. embassy cable ...

Recommended for you

Ebola virus in Africa outbreak is a new strain

19 hours ago

The Ebola virus that has killed scores of people in Guinea this year is a new strain—evidence that the disease did not spread there from outbreaks in some other African nations, scientists report.

User comments : 0

More news stories

Classifying cognitive styles across disciplines

Educators have tried to boost learning by focusing on differences in learning styles. Management consultants tout the impact that different decision-making styles have on productivity. Various fields have ...

Internet use may cut retirees' depression

Spending time online has the potential to ward off depression among retirees, particularly among those who live alone, according to research published online in The Journals of Gerontology, Series B: Psychological Sciences an ...

Tiny power plants hold promise for nuclear energy

Small underground nuclear power plants that could be cheaper to build than their behemoth counterparts may herald the future for an energy industry under intense scrutiny since the Fukushima disaster, the ...