Fractional dose of scarce meningitis vaccine may be effective in outbreak control

Dec 05, 2008

One fifth of the standard dose of a commonly used meningitis vaccine may be as effective as using the full dose. This new finding should allow scarce vaccine resources to be stretched further, especially during epidemics in Africa.

In a study initiated by the Norwegian Institute of Public Health, together with Epicentre (the research arm of Doctors Without Borders/Médecins Sans Frontières), and Mbarara University of Science and Technology in Uganda, immune responses in patients receiving smaller doses of a meningitis vaccine were found to be comparable to a full dose.

In 2004, a randomized clinical trial of 750 healthy volunteers (2-19 years old) took place in Uganda. Their immune response, assessed by serum bactericidal activity (SBA), was measured for 1/5 and 1/10 doses compared to a full dose. SBA response and safety/tolerability using 1/5 dose were comparable to a full dose for three serogroups (A, Y, W135), but not a fourth (C).

The results have now been published in PLoS Neglected Tropical Diseases.

Source: Norwegian Institute of Public Health

Explore further: Global Ebola conference seeks end to W.Africa outbreak

add to favorites email to friend print save as pdf

Related Stories

Brazil receives macaw pair from Germany

5 minutes ago

A pair of endangered blue macaws of the kind made famous by the hit animated "Rio" movies arrived in Brazil from Germany on Tuesday as part of a drive to ensure the bird's survival.

Recommended for you

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.