Fractional dose of scarce meningitis vaccine may be effective in outbreak control

Dec 05, 2008

One fifth of the standard dose of a commonly used meningitis vaccine may be as effective as using the full dose. This new finding should allow scarce vaccine resources to be stretched further, especially during epidemics in Africa.

In a study initiated by the Norwegian Institute of Public Health, together with Epicentre (the research arm of Doctors Without Borders/Médecins Sans Frontières), and Mbarara University of Science and Technology in Uganda, immune responses in patients receiving smaller doses of a meningitis vaccine were found to be comparable to a full dose.

In 2004, a randomized clinical trial of 750 healthy volunteers (2-19 years old) took place in Uganda. Their immune response, assessed by serum bactericidal activity (SBA), was measured for 1/5 and 1/10 doses compared to a full dose. SBA response and safety/tolerability using 1/5 dose were comparable to a full dose for three serogroups (A, Y, W135), but not a fourth (C).

The results have now been published in PLoS Neglected Tropical Diseases.

Source: Norwegian Institute of Public Health

Explore further: Treatment for deadly yeast disease reduced to three days

add to favorites email to friend print save as pdf

Related Stories

A digital version of you

Mar 12, 2014

When NASA's Mars Rover Opportunity sends a photograph of the alien landscape back to Earth, it relays the information as digital data, a series of ones and zeros that computers assemble into pictures that ...

UNICEF discloses vaccine prices for 1st time

May 29, 2011

UNICEF is for the first time publicizing what drugmakers charge it for vaccines, as the world's biggest buyer of lifesaving immunizations aims to spark price competition in the face of rising costs.

ActHIB vaccine recalled in Japan

Mar 11, 2011

Sanofi Pasteur and Daiichi Sankyo on Friday announced a recall of the ActHIB vaccine in Japan after an "unidentified substance" was found in two syringes.

US cable: Pfizer sought dirt on Nigerian official

Dec 10, 2010

(AP) -- Drug maker Pfizer Inc. hired investigators to uncover "corruption links" to Nigeria's embattled former attorney general in an attempt to stop federal cases over a 1996 drug study, according to a U.S. embassy cable ...

Recommended for you

Saudi Arabia reports pilgrim infected with MERS

3 hours ago

In the past 24 hours, Saudi Arabia has reported four new deaths from a Middle East virus related to SARS and 36 more cases of infection, including a Turkish pilgrim in Mecca.

User comments : 0

More news stories

Autism Genome Project delivers genetic discovery

A new study from investigators with the Autism Genome Project, the world's largest research project on identifying genes associated with risk for autism, has found that the comprehensive use of copy number variant (CNV) genetic ...

Study suggests targeting B cells may help with MS

A new study suggests that targeting B cells, which are a type of white blood cell in the immune system, may be associated with reduced disease activity for people with multiple sclerosis (MS). The study is released today ...

Study links California drought to global warming

While researchers have sometimes connected weather extremes to man-made global warming, usually it is not done in real time. Now a study is asserting a link between climate change and both the intensifying California drought ...