Secreted protein sends signal that fat is on the way

Dec 02, 2008

After you eat a burger and fries or other fat-filled meal, a protein produced by the liver may send a signal that fat is on the way, suggests a report in the December issue of the journal Cell Metabolism, a Cell Press publication.

Researchers have found in mice that the liver produces a protein called adropin, which rises in response to high-fat foods and falls after fasting. The protein seems to play a role in governing the activity of other metabolic genes, particularly those involved in the production of lipids from carbohydrates. Studies of the protein in obese animals suggest that it also plays a role in insulin response and in preventing the buildup of fat in the liver (a condition known as nonalcoholic fatty liver disease), the researchers said.

"What is remarkable is that it appears that this factor is specifically regulated by the fat content of the diet," making it one of the first such factors ever discovered, said Andrew Butler of Pennington Biomedical Research Center, part of the Louisiana State University System. (The findings follow another report in the November 26th issue of the journal Cell of a phospholipid produced by the gut that rises after a fatty meal, signaling the brain to eat less.)

The new results suggest that treatments designed to deliver adropin or otherwise boost its levels may hold promise in the war against obesity and associated metabolic disorders, including fatty liver disease and type 2 diabetes.

Indeed, Butler's team found that animals that become obese after eating a high-fat diet for a period of 3 months or due to a genetic mutation don't produce adropin normally. However, obese animals that are manipulated to produce excess adropin or that are given the protein show less fat in their livers and become more responsive to insulin. The mice also ultimately eat less and lose weight, but the other metabolic improvements do not depend on the animals' shrinking waistlines, Butler said.

"The good news is that when you provide a synthetic version of the peptide, it reverses some of the consequences of obesity," he said.

Butler noted, however, that there is still plenty left to learn. For instance, they would like to know whether mice that lack adropin become obese and show evidence of the metabolic syndrome, a cluster of diseases associated with obesity and insulin resistance. The protein is also produced in the brain, suggesting it may also affect behavior and metabolism in as-yet-undiscovered ways. The clinical promise of adropin will depend on whether the relationships between the protein, diet, and metabolism seen in mice will hold in human patients.

The researchers aren't yet certain exactly how adropin works its magic. Its benefits could involve effects within the liver and/or hormonal actions on other body tissues, they said. The answers to those questions will require further investigation.

"In summary," the researchers wrote, "adropin is a newly discovered secreted peptide that is involved in energy homeostasis and lipid metabolism … Adropin may form the basis for the development of new therapeutic targets for treating metabolic disorders associated with obesity."

Source: Cell Press

Explore further: Scientists seek cure for devastating witches' broom disease of the chocolate tree

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Is fleet diversity key to sustainable fisheries?

1 hour ago

Concern about fisheries is widespread around the world. Over the past several decades, a robust discussion has taken place concerning how to manage fisheries better to benefit ecosystems and humans. Much of the discussion ...

Strange, fanged deer persists in Afghanistan

1 hour ago

More than 60 years after its last confirmed sighting, a strange deer with vampire-like fangs still persists in the rugged forested slopes of northeast Afghanistan according to a research team led by the Wildlife ...

Captive rhinos exposed to urban rumbles

2 hours ago

The soundtrack to a wild rhinoceros's life is wind passing through the savannah grass, birds chirping, and distant animals moving across the plains. But a rhinoceros in a zoo listens to children screaming, cars passing, and ...

'Divide and rule'—raven politics

4 hours ago

Mythology has attributed many supernatural features to ravens. Studies on the cognitive abilities of ravens have indeed revealed that they are exceptionally intelligent. Ravens live in complex social groups ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.