ER/PR negative tumors associated with insurance status

Nov 18, 2008

African-American women are at a higher risk for ER/PR negative breast cancer. A new study, to be presented at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research, found that race, socioeconomic characteristics and other tumor characteristics are all important predictors of having ER/PR negative breast cancer.

ER/PR negative breast cancer has a poorer prognosis than hormonally-responsive cancer because treatment options are more limited.

In statistical models adjusted only for age, the study found that women who are uninsured or insured through Medicaid were 1.5 times more likely to have ER/PR negative tumors. Women who resided in low education versus high education zip codes were 1.6 times more likely to be diagnosed with ER/PR negative tumors. These findings were attenuated after controlling for race and other tumor characteristics which are highly associated with ER/PR status.

The risk of ER/PR negative breast cancers for African-American women dropped from 2.26 to 1.85 after controlling for socioeconomic status, stage at diagnosis, tumor size and histologic type.

"Hopefully, these findings will make us more aware that this more severe type of breast cancer is hitting minority and medically underserved women hardest, and we need to work toward finding prevention and therapeutic strategies," said Elizabeth Ward, Ph.D., director of cancer surveillance research at the American Cancer Society.

Ward and colleagues studied the relationship between race, socioeconomics and breast cancer using the National Cancer Database, which collects data for approximately 1,500 cancer hospitals, representing 70 percent of cancer patients in the United States.

After excluding those women with missing information on ER/PR status, researchers were left with 175,820 women who were diagnosed with breast cancer.

"It appears that multiple factors contribute to the risk for ER/PR negative breast cancer. Some of these risk factors appear to be more common in poor and African-American women," Ward said.

Source: American Association for Cancer Research

Explore further: Study reveals a cause of poorer outcomes for African-American patients with breast cancer

Related Stories

US govt sued over sea turtles snared in shrimp nets

5 hours ago

Tens of thousands of endangered sea turtles die every year in the United States when they are inadvertently snared in shrimp nets, an environmental group alleges, filing a lawsuit Wednesday against the government.

EU alleges Google's abuses hurt consumers, innovation

5 hours ago

The European Union's escalating legal attack on Google is likely to ignite a debate about whether the Internet search leader makes life more convenient for consumers or abuses its power to squeeze out rivals ...

Space open for business, says Electron launch system CEO

5 hours ago

Space, like business, is all about time and money, said Peter Beck, CEO of Rocket Lab, a US company with a New Zealand subsidiary. The problem, he added, is that, in cost and time, space has remained an incredibly ...

EU action on Google marks divergence with Washington

5 hours ago

The EU antitrust complaint filed Wednesday against Google represents a sharp divergence with Washington, which dropped a similar investigation two years ago, citing a lack of evidence against the Internet ...

Recommended for you

DNA blood test detects lung cancer mutations

Apr 17, 2015

Cancer DNA circulating in the bloodstream of lung cancer patients can provide doctors with vital mutation information that can help optimise treatment when tumour tissue is not available, an international group of researchers ...

Tumors prefer the easy way out

Apr 17, 2015

Tumor cells become lethal when they spread. Blocking this process can be a powerful way to stop cancer. Historically, scientists thought that tumor cells migrated by brute force, actively pushing through whatever ...

User comments : 2

Adjust slider to filter visible comments by rank

Display comments: newest first

E_L_Earnhardt
not rated yet Nov 18, 2008
Dark skin absorbs more UV heating and ray penetrating!
raorganicspa
not rated yet Dec 24, 2008
Thank you very much for the informative post and thanks for the sharing.

http://www.secure...ucts.php

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.