Genes associated with fat metabolism could increase kidney cancer risk

Nov 17, 2008

A team of international scientists has identified three genes associated with the body's processing of fats that may increase susceptibility to kidney cancer. The findings were presented at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research.

The researchers found that variations within three genes associated with lipid peroxidation – the process of breaking down fats and lipids when exposed to oxygen – could increase a person's risk of kidney cancer. Scientists have suspected lipid peroxidation as a unifying mechanism through which risk factors such as obesity, hypertension and smoking could damage kidney tissue and lead to kidney cancer.

"Obesity, hypertension and smoking have been the only established risk factors for kidney cancer, but they account for only 50 percent of cases," said lead author Lee E. Moore, Ph.D., M.P.H., an epidemiologist and investigator at the National Cancer Institute. "Our study suggests that common genetic variation may account for some of the increased risk in the other half of cases. This is the first and largest study of renal cell cancer to evaluate the influence of these genes."

For the study, Moore and a group of international colleagues studied blood DNA from 987 kidney cancer patients and 1,298 healthy counterparts living in Central and Eastern Europe, which have the highest rates of kidney cancer worldwide. The scientists analyzed DNA for hundreds of variations within 38 genes known to play a role in lipid peroxidation, inflammation and oxidative stress.

Variants of two genes were associated with increased risk of kidney cancer: nitric oxide synthase 2A (NOS2A), which increases levels of nitric oxide, a chemical that promotes free radical damage to cells; and prostaglandin-endoperoxide 2 (PTGS2), which produces prostaglandins, compounds that cause inflammation. Variants of a third gene, apolipoprotein E1 (ApoE1), which helps break down and remove triglycerides from the blood and liver, were associated with a reduction in risk for the disease.

Replication and fine mapping studies will be required to confirm these findings, Moore said. She is planning another study to look at these genetic variants among white and African-American kidney cancer patients in the United States.

Kidney cancer, one of the 10 most common forms of the disease, has been increasing in incidence in the United States and worldwide since the 1970s, Moore said.

Source: American Association for Cancer Research

Explore further: Immunotherapy could stop resistance to radiotherapy

add to favorites email to friend print save as pdf

Related Stories

Occupational sunlight exposure and kidney cancer risk in men

Mar 08, 2010

According to a new study, men employed in occupations with potential exposure to high levels of sunlight have a reduced risk of kidney cancer compared with men who were less likely to be exposed to sunlight at work. The study ...

The promise and peril of nanotechnology

Mar 26, 2014

Scientists at Northwestern University have found a way to detect metastatic breast cancer by arranging strands of DNA into spherical shapes and using them to cover a tiny particle of gold, creating a "nano-flare" ...

Pets and anesthesia

Mar 21, 2014

Have you been avoiding getting your pet regular dental care? You're not alone. Most pet owners understand that in animals—just as in people—good oral health is conducive to overall well-being, says Gillian Fraser, V00, ...

Recommended for you

Americans undergo colonoscopies too often, study finds

16 hours ago

Colonoscopies are a very valuable procedure by which to screen for the presence of colorectal cancer. However, it seems that healthy Americans who do undergo this sometimes uncomfortable examination often ...

User comments : 0