New biomarker for heart failure identified

Nov 12, 2008

Blood levels of resistin, a hormone produced by fat cells, can independently predict an individual's risk of heart failure, cardiologists at Emory University School of Medicine have found.

Their findings were presented Nov. 12 at the American Heart Association Scientific Sessions conference in New Orleans.

"This is one of the strongest predictors of new-onset heart failure we've been able to find, and it holds up even when you control for other biomarkers and risk factors including high blood pressure and diabetes," says Javed Butler, MD, MPH, associate professor of medicine and director of heart failure research at Emory University School of Medicine.

The finding comes out of the Health ABC (Aging and Body Composition) study, sponsored by the National Institute on Aging of the National Institutes of Health. The Health ABC study followed 3000 elderly people in the Pittsburgh and Memphis areas over seven years starting in 1998.

Although scientists don't know the exact function of resistin, it appears to be associated with both inflammation and insulin resistance, says Vasiliki Georgiopoulou, MD, a post-doctoral research fellow with Butler who presented these findings. "Recent laboratory studies have also shown that resistin decreases the ability of rats' heart muscles to contract," she adds.

In the Health ABC study, the risk of new onset heart failure increased by 38 percent for every 10 nanograms per milliliter increase in resistin levels in blood. Resistin was a stronger predictor of heart failure risk than other inflammatory markers linked to heart disease, such as C-reactive protein, the researchers found.

"Considering the increasing number of people who are obese or have diabetes, very many of them are going to be at some level of risk for heart failure later in life," Butler says. "The value of a marker such as resistin may be in accurately identifying among this large population of at-risk individuals who is at the highest risk and then targeting interventions to those people."

Source: Emory University

Explore further: A novel therapy for sepsis?

add to favorites email to friend print save as pdf

Related Stories

Ocean warming affecting Florida reefs

1 hour ago

Late-summer water temperatures near the Florida Keys were warmer by nearly 2 degrees Fahrenheit in the last several decades compared to a century earlier, according to a new study by the U.S. Geological Survey.

Networking can make some feel 'dirty,' says new study

1 hour ago

If schmoozing for work leaves you with a certain "ick" factor, that's not just awkwardness you're feeling. Professional networking can create feelings of moral impurity and physical dirtiness, shows a new ...

Recommended for you

A novel therapy for sepsis?

13 hours ago

A University of Tokyo research group has discovered that pentatraxin 3 (PTX3), a protein that helps the innate immune system target invaders such as bacteria and viruses, can reduce mortality of mice suffering ...

Cellular protein may be key to longevity

Sep 15, 2014

Researchers have found that levels of a regulatory protein called ATF4, and the corresponding levels of the molecules whose expression it controls, are elevated in the livers of mice exposed to multiple interventions ...

Gut bacteria tire out T cells

Sep 15, 2014

Leaky intestines may cripple bacteria-fighting immune cells in patients with a rare hereditary disease, according to a study by researchers in Lausanne, Switzerland. The study, published in The Journal of Experimental Me ...

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

ammal
not rated yet Aug 06, 2009
Dear Sir
Can you help me to find papers about the resistin and its effect in obese patient with atherosclerosis and ischemic heart disease and I wonder if you can help me to find scholarship for the project of PhD. I would like to express my fmiration of your elegant fields of research. Iam Ammal Esmaeel Ibrahim female. from Iraq Iam foyer to find an appartaimty to be involved as a full Time for scholarship for project of PhD. Student of your department. Iam seeking for a scholarship to cover tuition feeds and living expevses. I hope to accept my required and my wish come true to completing my study in chemistry science because I can not completing my study in iraq and I think you have idea a bout the situation in iraq and my family that consist of nine people make an another problem is the money problem. (Pleas can you help me to completing my PROJECT of PhD (PhD. in clinical biochemistry science). would you mind directing me learn to apply and if there is any opportunities for getting Scholarship from your University thank you to read my message pleas answer me as soon as possible
With my best regards.
Ammal Esmaeel Ibrahim
emil: aammll1984@yahoo.com
cv

Ammal Esmaeel Ibrahim
Iraq-Baghdad
AAMMLL1984@YAHOO.COM
OBJECTIVE: Iam seeking to continue my post-graduate studies for PhD
in chemistry science or biochemistry or Clinical Biochemistry science.
EDUCTION: - BSC in chemistry science ,AL-NAHRIN UNIVERSITY. Rank 3/27
I graduated from AL- NAHRAIN University College in June 2005 with rate 79.477.
- MSC in Clinical Biochemistry, AL-NAHRIN UNIVERSITY. Rank 2/19.
I graduated from AL- NAHRAIN University College in November 2007 with rate 83.6.
The language of study in my University is the ENGLISH language.
MY THESIS WAS ABOUT the relation between hyperprolactinemia and lipid profile among Iraqi patients

RELATED EXPERIENCE:
1- Computer course-office-2008
2- TOFEL-test preparation course 2008
3- Course in DNA Technique and Molecular Diagnosis using PCR Workshop with grad EXCELLENT 2007
4- Course in using windows operating system 2005.
5- Course in Medical Diagnostic tests 2007.
6- course in Teaching Methodology 2007.
7- course in English Language 2007.
8- My TOFEL SCORE (470)
HOBBIES: My hobbies including a love for reading. I also like to spend my free time running, watching television, hiking. Someday I would like to travel out of IRAQ to see different cultures special the india cultuer. finally, I also enjoy studing other objects like medical sciences.