Therapy may block expansion of breast cancer cells

Nov 05, 2008

Breast cancer stem cells are known to be involved in therapy resistance and the recurrence of cancerous tumors. A new study appearing in Clinical and Translational Science shows the mechanisms governing stem cell expansion in breast cancer (called Notch activity), and finds that therapy targeting a protein called cyclin D1 may block the expansion of cancerous stem cells.

The study, conducted by Dr. Richard Pestell and colleagues at Thomas Jefferson University, was the first to show that cyclin d1 is required for breast cancer growth in mice. As cyclin d1 is known to be over-expressed in human breast cancer, the findings may explain how cyclin d1 contributes to breast tumor growth, and provide the rationale for targeted therapies at cancerous stem cells in humans.

"Breast and other cancers are maintained through a population of cancer stem cells. By specifically targeting cancer stem cells we hope to reduce recurrence and improve therapy responses," says Pestell.

Cancer arises as a result of the accumulation of multiple genetic lesions that ultimately result in unregulated cell cycle, and Notch activity is a key determinant of the cellular development and differentiation related to this process. As Notch signaling is activated in human breast cancer, (and a negative regulator of Notch signaling reduces the disease), the molecular mechanisms regulating Notch activity are of fundamental importance for future therapy.

Source: Wiley

Explore further: Study finds potential new drug target for lung cancer

add to favorites email to friend print save as pdf

Related Stories

Standalone wireless info display device an easy fit

4 hours ago

A Latvian team has come up with a good-looking WiFi display device, connecting to the Internet using WiFi, which runs on a high-capacity built-in battery and tracks what's important to you. This is a standalone ...

Technology improves avalanche gear for backcountry skiers

5 hours ago

As outdoor recreation companies increasingly cater to skiers and snowboarders who like to venture beyond the groomed slopes at ski resorts and tackle backcountry terrain, they've put a special emphasis on gear and equipment ...

The elephant poaching business in numbers

5 hours ago

From the pittance paid to local poachers to a multi-billion dollar industry, here are some of the key numbers related to Africa's endangered elephants:

UN moves toward major treaty for ocean biodiversity

6 hours ago

UN member states agreed Saturday to begin negotiations on a treaty to protect marine biodiversity in ocean areas extending beyond territorial waters, in a move heralded by environmental organizations.

Recommended for you

Study finds potential new drug target for lung cancer

45 minutes ago

A new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a key enzyme and its associated metabolic programming may lead to novel drug development to treat lung cancer.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.