If the diabetes has a direct carcinogenetic effect?

Oct 29, 2008

The association of DM2 with solid tumors, and particularly with HCC, has been long suspected and several studies have reported increased mortality rates for neoplastic diseases in patients with DM2. However, the temporal relationship between onset of diabetes and development of HCC, and the clinical and metabolic characteristics of patients with DM2 and HCC have not been well examined.

A research article to be published on October 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Valter Donadon from Pordenone Hospital of Italy investigated the relationships between DM2 and risk of HCC in a large population based case-control study. They enrolled 465 consecutive patients with HCC compared with an age and sex matched control group of 490 subjects.

Their results confirm that patients with DM2 have a significantly increased risk of HCC, independent of cofactors such as HBV and HCV infection and alcohol intake, and demonstrate that DM2 pre-exists to the development of HCC in most cases, suggesting that DM2 is more likely a concourse rather than merely a consequence of the liver tumor. This conclusion is also supported by the finding of a similar frequency and severity of DM2 in patients with small HCC detected during follow-up of cirrhosis and in those with more advanced and diffuse cancers detected outside of a surveillance program. The observation that patients with DM2, particularly males, treated with insulin had an increased frequency of HCC is intriguing and clinically relevant. These patients are those often showing the highest insulin blood levels, and this might contribute to facilitate the development of HCC.

Source: World Journal of Gastroenterology

Explore further: Second western Minnesota turkey farm hit by bird flu outbreak

add to favorites email to friend print save as pdf

Related Stories

DARPA seeks new positioning, navigation, timing solutions

3 hours ago

The Defense Advanced Research Projects Agency (DARPA), writing about GPS, said: "The military relies heavily on the Global Positioning System (GPS) for positioning, navigation, and timing (PNT), but GPS access is easily blocked by methods such as jamming. In addition, many environments in which our mil ...

Lights out in Australia as Earth Hour kicks off

3 hours ago

The Sydney Harbour Bridge and the sails on the nearby Opera House went dark Saturday, as lights on landmarks around Australia were switched off for the global climate change awareness campaign Earth Hour.

Future US Navy: Robotic sub-hunters, deepsea pods

7 hours ago

The robotic revolution that transformed warfare in the skies will soon extend to the deep sea, with underwater spy "satellites," drone-launching pods on the ocean floor and unmanned ships hunting submarines.

Recommended for you

Third Minnesota turkey farm hit by bird flu outbreak

5 hours ago

An outbreak of a bird flu strain that's deadly to poultry deepened Saturday when state and federal officials confirmed a third Minnesota turkey farm has been infected, this time in one of the state's top poultry producing ...

Nocturnal GERD tied to non-infectious rhinitis

Mar 27, 2015

(HealthDay)—Nocturnal gastroesophageal reflux disease (GERD) appears to be a risk factor for non-infectious rhinitis (NIR), according to a study published online March 24 in Allergy.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.