A new insight on ethanol-induced gastric mucosa injury

Oct 23, 2008

Many people all over the world indulge themselves in drinking, which is correlated to a wide spectrum of medical, psychological, behavioral, and social problems. It is well known that chronic alcohol abuse may induce gastrointestinal dysfunction, chronic atrophic gastritis and is closely related with gastric carcinoma. However, the detailed mechanism by which ethanol affects the gastrointestinal mucosa remains to be elucidated.

A research article to be published on October 14, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Ren from Gastroenterology Division, Zhongshan Hospital of Xiamen University, systematically evaluated gastric mucosa alteration related to ethanol.

They found that the gastric mucosal lesion index was correlated with the malondiadehyde (MDA) content in gastric mucosa. As the concentration of ethanol was elevated and the exposure time to ethanol was extended, the contentof MDA in gastric mucosa increased and the extent of damage aggravated. The ultrastructure of mitochondria was positively related to the ethanol concentration
and exposure time. The expression of mtDNA ATPase subunits 6 and 8 mRNA declined with the increasing MDA content in gastric mucosa after gavage with ethanol.

They concluded that Ethanol-induced gastric mucosa injury is related to oxidative stress, which disturbs energy metabolism of mitochondria and plays a critical role in the pathogenesis of ethanol-induced gastric mucosa injury.

Source: World Journal of Gastroenterology

Explore further: Smartphone experiment tracks whether our life story is written in our gut bacteria

add to favorites email to friend print save as pdf

Related Stories

Leukemia-related protein 16 and colorectal carcinoma

Apr 09, 2010

A research team from China investigated the expression of leukemia-related protein 16 (LRP16) in colorectal cancer and normal mucosas and possible relationship between LRP16 expression and clinicopathological variables. Their ...

Nonspecific marker of non-erosive reflux disease

Mar 30, 2010

Non-erosive reflux disease (NERD) is the most common disorders of the gastrointestinal tract. However, diagnosis of NERD is not objective. A research group in China investigated esophageal mucosal damage in response to various ...

Yes-associated protein: Early diagnosis of gastric carcinoma

Sep 17, 2009

Yes-associated protein (YAP) is a type of cellular adaptor protein and transcriptional co-activator. In recent years, some investigators have found YAP to be overexpressed and highly activated in hepatic cancers and mammary ...

Recommended for you

Monitoring the rise and fall of the microbiome

6 hours ago

Trillions of bacteria live in each person's digestive tract. Scientists believe that some of these bacteria help digest food and stave off harmful infections, but their role in human health is not well understood.

Antioxidant biomaterial promotes healing

14 hours ago

When a foreign material like a medical device or surgical implant is put inside the human body, the body always responds. According to Northwestern University's Guillermo Ameer, most of the time, that response can be negative ...

Immune response may cause harm in brain injuries, disorders

16 hours ago

Could the body's own immune system play a role in memory impairment and cognitive dysfunction associated with conditions like chronic epilepsy, Alzheimer's dementia and concussions? Cleveland Clinic researchers believe so, ...

User comments : 0