Study examines association between caffeine consumption and breast cancer risk

Oct 13, 2008

Caffeine consumption does not appear to be associated with overall breast cancer risk, according to a report in the October 13 issue of Archives of Internal Medicine. However, there is a possibility of increased risk for women with benign breast disease or for tumors that are hormone-receptor negative or larger than 2 centimeters.

Caffeine is probably the most commonly consumed drug worldwide, present in coffee, tea, chocolate and some medications, according to background information in the article. It was hypothesized that caffeine may increase the risk of breast cancer after a study showed that women with non-cancerous breast disease experienced relief from their symptoms after removing caffeine from their diet.

Ken Ishitani, M.D., Ph.D., of Brigham and Women's Hospital and Harvard Medical School, Boston, and Tokyo Women's Medical University, Japan, and colleagues studied 38,432 women 45 years or older who provided dietary information in 1992-1995. Over an average of 10 years of follow-up, 1,188 of the women developed invasive breast cancer.

"Consumption of caffeine and caffeinated beverages and foods was not statistically significantly associated with overall risk of breast cancer," the authors write. Among women with benign breast disease, a non-significant positive association with breast cancer risk was observed for those in the highest quintile (one-fifth) of caffeine consumption and a significant association was observed for those in the highest category of coffee consumption (four cups or more daily).

Consuming caffeine was also associated with a 68 percent increased risk of estrogen receptor–negative and progesterone receptor–negative breast cancer, or tumors to which the hormones estrogen and progesterone do not bind, and a 79 percent increased risk for breast tumors larger than 2 centimeters.

"The mechanisms by which caffeine may affect breast carcinogenesis [cancer development] are complex and remain unclear," the authors write. "In the present investigation, caffeine consumption was associated with increased risk of breast cancers negative for both estrogen receptors and progesterone receptors or larger than 2 centimeters, which have less favorable prognoses. These findings indicate that caffeine consumption may affect breast cancer progression, and such an effect may be independent of the estrogen pathway." Further study is required to better understand caffeine's role, they note.

Source: JAMA and Archives Journals

Explore further: Pepper and halt: Spicy chemical may inhibit gut tumors

add to favorites email to friend print save as pdf

Related Stories

Breast milk transmits drugs and medicines to the baby

Jun 24, 2010

There is great confusion among the scientific community about whether women who are drug abusers should breast feed their babies. In order to shed some light on this issue, scientists from various Spanish ...

Coffee May Protect Against Disease

Jan 25, 2006

It's surprising when something that was once considered questionable for your health turns out to have health benefits, usually with the proviso to use it "in moderation." That happened with chocolate and alcohol, ...

Recommended for you

Pepper and halt: Spicy chemical may inhibit gut tumors

5 hours ago

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin – the active ingredient in chili peppers – produces chronic activation of a receptor on cells lining ...

Expressive writing may help breast cancer survivors

7 hours ago

Writing down fears, emotions and the benefits of a cancer diagnosis may improve health outcomes for Asian-American breast cancer survivors, according to a study conducted by a researcher at the University of Houston (UH).

Taking the guesswork out of cancer therapy

12 hours ago

Researchers and doctors at the Institute of Bioengineering and Nanotechnology (IBN), Singapore General Hospital (SGH) and National Cancer Centre Singapore (NCCS) have co-developed the first molecular test ...

Brain tumour cells found circulating in blood

13 hours ago

(Medical Xpress)—German scientists have discovered rogue brain tumour cells in patient blood samples, challenging the idea that this type of cancer doesn't generally spread beyond the brain.

International charge on new radiation treatment for cancer

14 hours ago

(Medical Xpress)—Imagine a targeted radiation therapy for cancer that could pinpoint and blast away tumors more effectively than traditional methods, with fewer side effects and less damage to surrounding tissues and organs.

User comments : 0