Study finds antioxidant deficiency linked to pulmonary hypertension

Sep 23, 2008

A recent study shows that a loss of antioxidants in the endothelial cells that line blood vessels in the lungs contributes to the loss of vasodilator effects and, ultimately, to the development of pulmonary hypertension. The findings appear in Clinical and Translational Science.

The study, led by Serpil Erzurum of the Cleveland Clinic, evaluated antioxidant activities in patients with idiopathic pulmonary arterial hypertension (IPAH), a fatal disease characterized by progressive increase in pulmonary artery pressure and vascular resistance.

Erzurum's study found that the inactivation of these oxidants inside the cell is achieved mainly by the cell's own line of defense against oxidants. Additionally, the researchers determined that this process may contribute to low levels of nitric oxide, identified in IPAH and a fundamental component in the pathogenesis of pulmonary hypertension.

According to Dr. Erzurum, there is a potential long-term benefit to the care of patients with IPAH due to the study's findings. "Antioxidant augmentation in patients might be used to increase nitric oxide vasodilator effects, reduce pulmonary artery pressures and potentially improve clinical outcomes," she said.

Source: Wiley

Explore further: Researchers develop a new drug to combat the measles

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Malaysia reports first Asian death from MERS virus

4 hours ago

A Malaysian man who went on a pilgrimage to Saudi Arabia has become the first death in Asia from Middle East respiratory syndrome, while the Philippines has isolated a health worker who tested positive for the deadly coronavirus.

Philippines quarantines man over MERS fears

4 hours ago

Philippine health authorities said Wednesday they have quarantined a Filipino who arrived from the Middle East because he tested positive for the deadly MERS virus.

User comments : 0

More news stories

US judge overturns state's abortion law

A federal judge on Wednesday overturned a North Dakota law banning abortions when a fetal heartbeat can be detected, as early as six weeks into pregnancy and before many women know they're pregnant.

Meteorites yield clues to Martian early atmosphere

(Phys.org) —Geologists who analyzed 40 meteorites that fell to Earth from Mars unlocked secrets of the Martian atmosphere hidden in the chemical signatures of these ancient rocks. Their study, published ...

Japan lawmakers demand continued whaling

Japanese lawmakers on Wednesday demanded the government redesign its "research" whaling programme to circumvent an international court ruling that described the programme as a commercial hunt dressed up as ...