A case of false positive octreoscan in Crohn's disease

Sep 21, 2008

Neuroendocrine tumors, such as carcinoid tumors, overexpress somatostatin receptors in their membranes. Octreotide is an analogue whose molecule is a shortened version of somatostatin's with a high affinity for these receptors. The labelled form of octreotide is able to be imaged in scans (Octreoscan) and, therefore, pathological conditions overexpressing somatostatin receptors are easily recognized in this technique. Specifically, in the case of the detection of carcinoid tumors, the Octreoscan has sensitivity nearly to 90%.

A research article to be published on September 14, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Alberto Fernandez from POVISA Hospital in Spain presents a case of a patient with a high suspicious of ileal carcinoid tumor (according to CT-scan and colonoscopy results) with a positive Octreoscan, showing uptake in the same bowel reported as pathological in CT. The patient underwent surgery and histological analysis reported Crohn's disease.

This article is the second report of CD a cause of false positive in octeotride scan. In order to explain this abnormal uptake, immunohistochemical studies were performed but the authors did not find somatostatine receptors in the sample. In the previous report published of CD mimicking an ileal carcinoid there is no evidence that somatostatin receptors were determined.

The authors did not find any explanation, and concluded encouraging physicians to be aware of CD as a cause of false positive results of Octreoscan and that further studies should be made in order to assess the possible causes of this abnormal uptake.

Source: World Journal of Gastroenterology

Explore further: Swatting chikungunya

add to favorites email to friend print save as pdf

Related Stories

For gamers, waiting can be the hardest part

2 hours ago

When it comes to video games, are they better late than never? At this week's GameStop Expo, the video game retailer's annual consumer-centric event, more than 3,000 attendees had the chance to test drive ...

The ozone hole has stabilized—some questions remain

2 hours ago

The production and consumption of chemical substances threatening the ozone layer has been regulated since 1987 in the Montreal Protocol. Eight international expert reports have since been published, which ...

Recommended for you

Swatting chikungunya

2 hours ago

Summer days may be waning, but health officials are still on high alert for new cases of chikungunya, a painful mosquito-borne virus that spread to the United States from the tropics earlier this year. ...

Sierra Leone readies for controversial Ebola lockdown

2 hours ago

Sierra Leone prepared Thursday for an unprecedented three-day nationwide lockdown to contain the deadly spread of the Ebola virus in a controversial move which experts claimed could worsen the epidemic.

Nepal adopts jab to boost polio fight

2 hours ago

Nepal on Thursday launched a drive to eradicate polio by supplementing oral vaccines with an injection that experts say will boost children's immunity against the disease.

User comments : 0