Gastric cancer with 3 pathological features

Sep 18, 2008

Primary carcinoma of the stomach is almost always adenocarcinoma or signet ring cell carcinoma and there are few reports of choriocarcinoma or neuroendocrine cell carcinoma. We report a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma. This is the first reported case of gastric cancer with these three pathological features.

A case article to be published on 28 May 2008 in the World Journal of Gastroenterology addresses this report. The research team led by Prof. Yasumitsu Hirano from Kanazawa University Graduate school of Medical Science described a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma.

They reported that a 85-year-old man presented to the hospital because of appetite loss. Gastric fiberscopy revealed a large tumor occupying the cardial region and anterior wall of the gastric body. The patient underwent total gastrectomy with lymphnode dissection and partial resection of the liver. In the gastric tumor, choriocarcinoma, small cell carcinoma and tubular adenocarcinoma were existed. The choriocarcinomatous foci contained cells positive for beta-subunit of human chorionic gonadotropin (B-hCG) and human placental lactogen mainly in syncytiotrophoblastic cells. The small cell carcinomatous foci contained cells positive for synaptophysin, neuron-specific enolase (NSE), and chromogranin A.

The prognosis for gastric adenocarcinoma with choriocarcinoma and neuroendocrine cell carcinoma is exceedingly poor. This patient died about 2 month after the first complaint from hepatic failure. This is the first reported case of gastric cancer with these three pathological features.

Source: World Journal of Gastroenterology

Explore further: Test predicts response to treatment for complication of leukemia stem cell treatment

add to favorites email to friend print save as pdf

Related Stories

Robotic surgery for head and neck cancer shows promise

Dec 20, 2010

Less-invasive robotic surgery for upper airway and digestive track malignant tumors is as effective as other minimally invasive surgical techniques based on patient function and survival, according to University of Alabama ...

ASGE issues guideline on ethnic issues in endoscopy

Jun 03, 2010

The American Society for Gastrointestinal Endoscopy (ASGE) has issued guidelines addressing ethnicity, gastrointestinal diseases and endoscopic procedures. The guideline suggests that colorectal cancer screening should begin ...

Recommended for you

Suppressing a protein reduces cancer spread in mice

5 hours ago

Scientists have found that decreasing the levels of or blocking a specific protein commonly found in humans and many other animals allowed them to slow the spread of two different kinds of cancer to the lungs ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.