A breakthrough in contrast-enhanced intraoperative ultrasonography

Sep 18, 2008

The present brief clinical report showed that Contrast-enhanced intraoperative ultrasonography (CE-IOUS) using a new microbubble agent, Sonazoid, can allow surgeons to investigate the whole liver with enough time and to find new metastases intraoperatively.

Contrast-enhanced intraoperative ultrasonography (CE-IOUS) seems more sensitive than conventional IOUS to identify new occult lesions during hepatectomy in patients with colorectal cancer liver metastases (CRCLM). However, conventional contrast mediums cannot provide enough time for repeat whole liver intraoperative scan, and further improvement of microbubble agent for CE-IOUS had been sought.

A brief clinical article to be published on January 28, 2008 in the World Journal of Gastroenterology addresses this question. A clinical team led by Dr. Nakano from Asahi-Chuo General Hospital used Sonazoid (perfluorobutane, GE Helthcare, Oslo, Norway), which is a new microbubble agent that provides late Kupffer-phase image.

They showed that CE-IOUS using Sonazoid provided the late Kupffer-phase image for at least 30 min following hepatic vascular-phase image for the first 10 min after the injection. They also showed that occult metastases, which had not been detected preoperatively by CT, MRI or CE-US, were newly found in two of the eight patients with CRCLM.

Sonazoid seems the most suitable microbubble agent for CE-IOUS, and may reduce intrahepatic recurrence and improve survival after hepatectomy in patients with CRCLM.

Source: World Journal of Gastroenterology

Explore further: Were clinical trial practices in East Germany questionable?

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Were clinical trial practices in East Germany questionable?

Oct 23, 2014

Clinical trials carried out in the former East Germany in the second half of the 20th century were not always with the full knowledge or understanding of participants with some questionable practices taking place, according ...

Schumacher's doctor sees progress after injury

Oct 23, 2014

A French physician who treated Michael Schumacher for nearly six months after the Formula One champion struck his head in a ski accident says he is no longer in a coma and predicted a possible recovery within three years.

User comments : 0