Does probiotic intervention induce the serum global lipid profile change?

Sep 18, 2008

The new global metabolic profiling techniques, like lipidomics as a branch of metabolomics, have made it possible to measure large numbers of different metabolites, and are currently being applied to increase our understanding of the health and disease continuum.

A Finland research group investigated the effect of a three weeks intervention of a probiotic LGG intervention on serum global lipidomics profiles in healthy adults. This will be published on 28 May 2008, in the World Journal of Gastroenterology.

The result showed that there were decreases in the levels of lysophosphatidylcholines (LysoGPCho), sphingomyelins (SM) and several glycerophosphatidylcholines (GPCho), and increases in triacylglycerols (TAG) in the probiotic LGG group. These changes may contribute, for example, to the metabolic events behind the beneficial effects of LGG on gut barrier function seen in previous studies.

This study, done in collaboration with research groups of Associate Professor Riitta Korpela and Professor Matej Orešič, was the first to characterise the effect of probiotics on global lipidomics profiles. There were indications that probiotic LGG intervention may lead to changes in global lipidomics profiles reflected in decreased LysoGPCho and SM, mainly decreased GPCho and mainly elevated TAG. In addition, among the inflammatory variables, IL-6 was moderately associated by changes in global lipidomics profiles, while there was only a weak association between the lipidomics profiles and the two other inflammatory markers, TNF-αand CRP.

The new analytical capacity of lipidomics as a branch of metabolomics can increase our understanding of lipid biology, improve the characterisation of global lipid profiles and result in the identification of previously unknown changes in lipid metabolism.

Probiotics have been mostly studied in the prevention and treatment of different gastrointestinal diseases and allergy, but the action mechanisms of probiotics are poorly understood. Metabolomics may provide powerful tools for identifying new biomarkers behind the clinical effects of probiotic intervention trials and for establishing relationships between molecular profiles and other known data from the same individual.

Source: World Journal of Gastroenterology

Explore further: 2015 match sees high proportion of unmatched seniors

Related Stories

Recommended for you

2015 match sees high proportion of unmatched seniors

Mar 30, 2015

(HealthDay)—About 6.1 percent of U.S. allopathic medical school seniors in the National Resident Matching Program (NRMP) were not placed into first-year residency positions, with a higher percentage of ...

What to do with kidneys from older deceased donors?

Mar 26, 2015

A new study highlights the best way to use kidneys from older deceased donors, providing the most benefits to patients and addressing the worsening organ shortage. The study's findings, which appear in an upcoming issue of ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.