Top-selling prescription drug mismarketed to women

Sep 17, 2008

Lipitor has been the top-selling drug in the world and has accounted for over $12 billion in annual sales. It has been prescribed to both men and women to lower cholesterol and reduce the risk of heart attack and stroke in patients with common risk factors for heart disease. However, a new study appearing in the Journal of Empirical Legal Studies was unable to find high quality clinical evidence documenting reduced heart attack risk for women in a primary prevention context. Furthermore, advertising omits label information relevant to women.

Theodore Eisenberg of Cornell Law School and Martin T. Wells of Cornell University assembled studies for a meta analysis of drugs' effects on cardiovascular risk, taking into account all relevant studies reporting risks for both men and women.

Not one of the studies that included women with a mixture of risk factors for heart attacks provided statistically significant support for prescribing Lipitor or other statins to protect against cardiovascular problems. Pfizer's claims of clinical proof that Lipitor reduces risk of heart attack in patients with multiple risk factors for heart disease does not appear to be scientifically supported for large segments of the female population.

In addition, Lipitor's advertising repeatedly fails to report that clinical trials were statistically significant for men but not for women. Unqualified advertising claims of protection against heart attacks may therefore be misleading. Pfizer's advertising also does not disclose critical portions of the Lipitor FDA-approved label, which acknowledges the absence of evidence with respect to women.

"Our findings indicate that each year, reasonably healthy women spend billions of dollars on drugs in the hope of preventing heart attacks but that scientific evidence supporting their hope does not exist," the authors conclude.

Source: Wiley

Explore further: FDA OKs Cubist antibiotic for serious infections

add to favorites email to friend print save as pdf

Related Stories

The truth about the war on wheat

Oct 03, 2014

If you believe the best-seller lists, the biggest bad in the supermarket aisles is not fat or sodium or sugar, but wheat. We have been warned that eating wheat makes our bellies fatter and triggers diseases ...

Climate change report identifies 'the most vulnerable'

Sep 22, 2014

Extreme weather events leave populations with not enough food both in the short- and the long-term. A new report by the Environmental Change Institute (ECI) at the School of Geography and the Environment ...

Poll surveys residents of two war-torn African nations

Sep 15, 2014

Researchers fanned out in one of the most dangerous corners of the globe late last year, asking residents of a brutalized part of the Democratic Republic of the Congo (DRC) their thoughts on violence, security, ...

Golden retriever study sniffs for cancer clues

Sep 11, 2014

(HealthDay)—Michael Court is a scientist and a dog lover, so he jumped at the chance to enroll his golden retriever in a nationwide study aimed at fighting cancer and other ills in canines.

Recommended for you

FDA OKs Cubist antibiotic for serious infections

11 hours ago

The Food and Drug Administration has approved a new medicine to fight complex infections in the abdomen and urinary tract, the fourth antibiotic the agency has approved since May.

Xtoro approved for swimmer's ear

Dec 18, 2014

(HealthDay)—Xtoro (finafloxacin otic suspension) eardrops have been approved by the U.S. Food and Drug Administration to treat swimmer's ear, clinically known as acute otitis externa.

Drug interaction identified for ondansetron, tramadol

Dec 18, 2014

(HealthDay)—In the early postoperative period, ondansetron is associated with increased requirements for tramadol consumption, according to a review and meta-analysis published online Dec. 10 in Anaesthesia.

New system targets germs in donated blood plasma

Dec 17, 2014

(HealthDay)—A new system designed to eliminate germs in donated blood plasma and reduce the risk of transmitting a plasma-borne infection has been approved by the U.S. Food and Drug Administration.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.