Safety of anti-malarial drugs in pregnancy must be monitored

Sep 09, 2008

There is an urgent need to develop systems to assess the safety of antimalarials in early pregnancy, says a new essay in this week's PLoS Medicine.

Feiko ter Kuile (Liverpool School of Tropical Medicine, Liverpool, UK) and colleagues report that the anti-malarial drugs artemisinins are effective and commonly used, but they have been shown to be toxic to embryos in animal models. Their safety in early human pregnancies remains uncertain, despite up to 10% of embryos being exposed to anti-malarial drugs in malaria endemic countries.

Because most of the approaches used in wealthier countries to evaluate a drug's toxicity in pregnancy do not apply in low income countries, the authors argue that we must establish an international antimalarial pregnancy exposure registry. This would enable a "targeted prospective pharmacovigilance approach and timely assessment of the risk–benefit profile of antimalarials," say ter Kuile and colleagues.

Source: Public Library of Science

Explore further: FDA OKs Merck tablet to reduce ragweed allergies

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Study recalculates costs of combination vaccines

9 hours ago

One of the most popular vaccine brands for children may not be the most cost-effective choice. And doctors may be overlooking some cost factors when choosing vaccines, driving the market toward what is actually a more expensive ...

Drug watchdog urges vigilance in cancer drug theft

13 hours ago

Europe's medicine watchdog urged doctors Thursday to be vigilant in administering the cancer drug Herceptin, vials of which had been stolen in Italy and tampered with before being sold back into the supply chain.

Pyridoxine-doxylamine drug safety data lacking

Apr 16, 2014

(Medical Xpress)—The most commonly prescribed drug for pregnant women suffering from morning sickness in their first trimester does not prevent birth defects even though drug safety data says it does, according to research ...

User comments : 0

More news stories

Chronic inflammation linked to 'high-grade' prostate cancer

Men who show signs of chronic inflammation in non-cancerous prostate tissue may have nearly twice the risk of actually having prostate cancer than those with no inflammation, according to results of a new study led by researchers ...

Turning off depression in the brain

Scientists have traced vulnerability to depression-like behaviors in mice to out-of-balance electrical activity inside neurons of the brain's reward circuit and experimentally reversed it – but there's ...

Better thermal-imaging lens from waste sulfur

Sulfur left over from refining fossil fuels can be transformed into cheap, lightweight, plastic lenses for infrared devices, including night-vision goggles, a University of Arizona-led international team ...

Hackathon team's GoogolPlex gives Siri extra powers

(Phys.org) —Four freshmen at the University of Pennsylvania have taken Apple's personal assistant Siri to behave as a graduate-level executive assistant which, when asked, is capable of adjusting the temperature ...