Safety of anti-malarial drugs in pregnancy must be monitored

Sep 09, 2008

There is an urgent need to develop systems to assess the safety of antimalarials in early pregnancy, says a new essay in this week's PLoS Medicine.

Feiko ter Kuile (Liverpool School of Tropical Medicine, Liverpool, UK) and colleagues report that the anti-malarial drugs artemisinins are effective and commonly used, but they have been shown to be toxic to embryos in animal models. Their safety in early human pregnancies remains uncertain, despite up to 10% of embryos being exposed to anti-malarial drugs in malaria endemic countries.

Because most of the approaches used in wealthier countries to evaluate a drug's toxicity in pregnancy do not apply in low income countries, the authors argue that we must establish an international antimalarial pregnancy exposure registry. This would enable a "targeted prospective pharmacovigilance approach and timely assessment of the risk–benefit profile of antimalarials," say ter Kuile and colleagues.

Source: Public Library of Science

Explore further: Most US babies get their vaccines, CDC says

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Most US babies get their vaccines, CDC says

Aug 28, 2014

(HealthDay)—The vast majority of American babies are getting the vaccines they need to protect them from serious illnesses, federal health officials said Thursday.

Expression of privilege in vaccine refusal

Aug 27, 2014

Not all students returning to school this month will be up to date on their vaccinations. A new study conducted by Jennifer Reich, a researcher at the University of Colorado Denver, shows that the reasons why children may ...

User comments : 0