Hydrogels provide scaffolding for growth of bone cells

Aug 17, 2008

Hyaluronic hydrogels developed by Carnegie Mellon University researchers may provide a suitable scaffolding to enable bone regeneration. The hydrogels, created by Newell Washburn, Krzysztof Matyjaszewski and Jeffrey Hollinger, have proven to encourage the growth of preosteoblast cells, cells that aid the growth and development of bone. Doctoral student Sidi Bencherif will present this research, Sunday, Aug. 17 at the 236th national meeting of the American Chemical Society in Philadelphia.

Currently, physicians are able to treat patients with damaged bone tissue, like those who have bone fractures that fail to heal, using demineralized bone matrix, a biological material obtained from cadavers. Demineralized bone matrix is rich in growth factor proteins which signal bone cells in the area to multiply and form complex bone tissue, while other proteins in the matrix regulate the activity of the growth factors. Demineralized bone matrix is in limited supply, and because it comes from a human donor, there is a risk of transmitting viruses to the recipient.

"Tissue engineering is an exciting field. We're creating solutions to problems that can significantly impact people's quality of life," said Washburn, an assistant professor of chemistry and biomedical engineering at Carnegie Mellon. "These gels have great promise in not only regenerating bone, but serving as a gene therapy delivery system."

Members of the Washburn lab have been developing synthetic alternatives to demineralized bone matrix. In the work being presented today, they created a flexible hydrogel using biologically active and degradable hyaluronic acid. Hydrogels, which are considered to be the state-of-the-art in tissue design, are made from polymers that swell in water to form a gel-like material. They interact with growth factors much like demineralized bone matrix does, providing scaffolding for bone cells to proliferate and form new tissue. The researchers found that, in vitro, the hydrogels promoted cell proliferation, differentiation and mineralization of pre-osteoblast cells.

Further research by the group has created a hybrid hydrogel that incorporates a nanogel structure. This new hydrogel promotes the differentiation of cells, much like the hyaluronic acid gel while also releasing nanogels in a controlled and targeted manner. The researchers hope that this structure could be used to partner tissue engineering with gene therapy.

Source: Carnegie Mellon University

Explore further: Doctoral student's work on cocoa research may yield sweet benefits for health

add to favorites email to friend print save as pdf

Related Stories

Is sending shoppers ads by Bluetooth just a bit creepy?

1 hour ago

Using Bluetooth wireless networking to send information to nearby smartphones, beacon technology could transform how retailers engage with their customers. But customers will notice how their information is ...

To save the birds, look to the fish

1 hour ago

Birds that dive for fish while wintering in the Salish Sea, located between British Columbia and Washington, are more likely to be in decline than nondiving birds with less specialized diets, according to ...

Recommended for you

NASA is catalyst for hydrogen technology

2 hours ago

NASA answered a call to help the world's largest aerospace company develop a better way to generate electricity for its aircraft. Instead, it wound up helping a very small technology company to thrive.

Triplet threat from the sun

20 hours ago

The most obvious effects of too much sun exposure are cosmetic, like wrinkled and rough skin. Some damage, however, goes deeper—ultraviolet light can damage DNA and cause proteins in the body to break down ...

User comments : 0